ArticlePNAS nexus2023
Inapparent infections shape the transmission heterogeneity of dengue.
Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases.The New England journal of medicine · 2025Trial
- Unrecognized Dengue Transmission in Socially Vulnerable Peri-Urban Neighborhoods of a Temperate Argentine City: Integrating Serology with Knowledge, Attitudes, and Practices.Epidemiologia (Basel, Switzerland) · 2026Article
- Direct and Indirect Entomological Efficacy of Targeted Indoor Residual Spraying againstbioRxiv : the preprint server for biology · 2026Article
- Anopheles stephensi larval habitat superproductivity and its relevance for larval source management in Ethiopia.Malaria journal · 2025Article
- Prolonged exposure to heat enhances mosquito tolerance to viral infection.Communications biology · 2025Article
- Simulation-based economic evaluation of the Wolbachia method in Brazil: a cost-effective strategy for dengue control.Lancet regional health. Americas · 2024Article
- Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential.Scientific reports · 2023Article
- Arbovirus Transmission Predictions Are Affected by Both Temperature Data Source and Modeling Methodologies across Cities in Colombia.Microorganisms · 2023Article
- Flying under the radar - impact and factors influencing asymptomatic DENV infections.Frontiers in cellular and infection microbiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
Abstract
Transmission heterogeneity, whereby a disproportionate fraction of pathogen transmission events result from a small number of individuals or geographic locations, is an inherent property of many, if not most, infectious disease systems. For vector-borne diseases, transmission heterogeneity is inferred from the distribution of the number of vectors per host, which could lead to significant bias in situations where vector abundance and transmission risk at the household do not correlate, as is the case with dengue virus (DENV). We used data from a contact tracing study to quantify the distribution of DENV acute infections within human activity spaces (AS), the collection of residential locations an individual routinely visits, and quantified measures of virus transmission heterogeneity from two consecutive dengue outbreaks (DENV-4 and DENV-2) that occurred in the city of Iquitos, Peru. Negative-binomial distributions and Pareto fractions showed evidence of strong overdispersion in the number of DENV infections by AS and identified super-spreading units (SSUs): i.e. AS where most infections occurred. Approximately 8% of AS were identified as SSUs, contributing to more than 50% of DENV infections. SSU occurrence was associated more with DENV-2 infection than with DENV-4, a predominance of inapparent infections (74% of all infections), households with high
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.