Evidence map›Paper›PMID 36909750›Full record

ReviewRSC advances2023

Success stories of natural product-derived compounds from plants as multidrug resistance modulators in microorganisms.

Xiaohan Zhai, Guoyu Wu, Xufeng Tao, Shilei Yang, Linlin Lv, Yanna Zhu, Deshi Dong, Hong Xiang

Abstract readReview
In one paragraph

Review in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Invasive Giant Goldenrod (Molecules (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Review
  7. Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026
    Review
  8. Article
  9. Article
  10. Polyphenolic compounds inFrontiers in pharmacology · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Antibacterial Activity of PeruvianInternational journal of microbiology · 2025
    Article
  15. Metabolic Comparison and Molecular Networking of Antimicrobials inInternational journal of molecular sciences · 2024
    Article
  16. Review
  17. Article
  18. Antibacterial and Antimycotic Activity ofPharmaceuticals (Basel, Switzerland) · 2023
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaohan ZhaiDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.
Guoyu WuDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.
Xufeng TaoDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.
Shilei YangDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.
Linlin LvDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.
Yanna ZhuDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.
Deshi DongDepartment of Pharmacy, First Affiliated Hospital of Dalian Medical University Dalian China dongdeshi@dmu.edu.cn xianghong@dmu.edu.cn.ORCID https://orcid.org/0000-0003-3266-4314
Hong XiangLaboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University Dalian China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microorganisms evolve resistance to antibiotics as a function of evolution. Antibiotics have accelerated bacterial resistance through mutations and acquired resistance through a combination of factors. In some cases, multiple antibiotic-resistant determinants are encoded in these genes, immediately making the recipient organism a "superbug". Current antimicrobials are no longer effective against infections caused by pathogens that have developed antimicrobial resistance (AMR), and the problem has become a crisis. Microorganisms that acquire resistance to chemotherapy (multidrug resistance) are a major obstacle for successful treatments. Pharmaceutical industries should be highly interested in natural product-derived compounds, as they offer new sources of chemical entities for the development of new drugs. Phytochemical research and recent experimental advances are discussed in this review in relation to the antimicrobial efficacy of selected natural product-derived compounds as well as details of synergistic mechanisms and structures. The present review recognizesand amplifies the importance of compounds with natural origins, which can be used to create safer and more effective antimicrobial drugs by combating microorganisms that are resistant to multiple types of drugs.

Identifiers

PMID36909750
PMCPMC9994607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.