Evidence map›Paper›PMID 36909597›Full record

ArticlebioRxiv : the preprint server for biology2023

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.

Anja Schmidt, Tara Finegan, Matthias Häring, Deqing Kong, Alexander G Fletcher, Zuhayr Alam, Jörg Grosshans, Fred Wolf, Mark Peifer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Anja SchmidtDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Tara FineganDepartment of Biology, University of Rochester, Rochester, New York, USA 14627-0211.
Matthias HäringGöttingen Campus Institute for Dynamics of Biological Networks, Georg August University, Hermann Rein Str. 3, 37075 Göttingen, Germany.
Deqing KongDepartment of Biology, Philipps University, Karl-von-Frisch-Straße 8, 35043 Marburg, Germany.
Alexander G FletcherSchool of Mathematics and Statistics & Bateson Centre, University of Sheffield, Sheffield, UK.
Zuhayr AlamDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Jörg GrosshansDepartment of Biology, Philipps University, Karl-von-Frisch-Straße 8, 35043 Marburg, Germany.
Fred WolfGöttingen Campus Institute for Dynamics of Biological Networks, Georg August University, Hermann Rein Str. 3, 37075 Göttingen, Germany.
Mark PeiferDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
University of North Carolina at Chapel Hill · USMax Planck Institute for Dynamics and Self-Organization · DEPhilipps University of Marburg · DEUniversity of Rochester · USUniversity of Sheffield · GB

Funding

Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
NIGMS NIH HHS R35 GM118096
6 · The paper itself

Abstract

During embryonic development dramatic cell shape changes and movements re-shape the embryonic body plan. These require robust but dynamic linkage between the cell-cell adherens junctions and the force-generating actomyosin cytoskeleton. Our view of this linkage has evolved, and we now realize linkage is mediated by a mechanosensitive multiprotein complex assembled via multivalent connections. Here we combine genetic, cell biological and modeling approaches to define the mechanism of action and functions of an important player,

Identifiers

PMID36909597
PMCPMC10002719
OpenAlexW4323075205

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.