Evidence map›Paper›PMID 36909568›Full record

ArticlebioRxiv : the preprint server for biology2023

Repetitive Spreading Depolarization induces gene expression changes related to synaptic plasticity and neuroprotective pathways.

Michela Dell'Orco, Jordan E Weisend, Nora I Perrone-Bizzozero, Andrew P Carlson, Russell A Morton, David N Linsenbardt, C William Shuttleworth

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michela Dell'OrcoDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
Jordan E WeisendDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
Nora I Perrone-BizzozeroDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
Andrew P CarlsonDepartment of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
Russell A MortonDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
David N LinsenbardtDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
C William ShuttleworthDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.
University of New Mexico · US

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Spreading Depolarizations and Neuronal VulnerabilityR01NS106901 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Claude W Shuttleworth · 2018 to 2026
$2.5M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS106901
6 · The paper itself

Abstract

Spreading depolarization (SD) is a slowly propagating wave of profound depolarization that sweeps through cortical tissue. While much emphasis has been placed on the damaging consequences of SD, there is uncertainty surrounding the potential activation of beneficial pathways such as cell survival and plasticity. The present study used unbiased assessments of gene expression to evaluate that compensatory and repair mechanisms could be recruited following SD, regardless of the induction method, which prior to this work had not been assessed. We also tested assumptions of appropriate controls and the spatial extent of expression changes that are important for

Indexed as

brain injurygene expressionpathway analysispreconditioningspreading depressionstroke

Identifiers

PMID36909568
PMCPMC10002705
OpenAlexW4322619823

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.