Evidence map›Paper›PMID 36909562›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.

Victor A Del Bene, Roy C Martin, Sarah A Brinkerhoff, Joseph W Olson, Matthew J Nelson, Dario Marotta, Christopher L Gonzalez, Kelly A Mills, Vidyulata Kamath, J Nicole Bentley and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Victor A Del BeneDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Roy C MartinDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Sarah A BrinkerhoffDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Joseph W OlsonDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Matthew J NelsonDepartment of Neurosurgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Dario MarottaDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Christopher L GonzalezDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Kelly A MillsDepartment of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Vidyulata KamathDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
J Nicole BentleyDepartment of Neurosurgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Barton L GuthrieDepartment of Neurosurgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Robert T KnightDepartment of Psychology, University of California, Berkeley, CA, USA.
Harrison C WalkerDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
University of Alabama at Birmingham · USJohns Hopkins University · USUniversity of California, Berkeley · US

Funding

Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's DiseaseUH3NS100553 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WALKER, HARRISON CARROLL · 2016 to 2021
$7.3M
NINDS NIH HHS UH3 NS100553
6 · The paper itself

Abstract

Objective: To investigate hemispheric effects of directional versus ring subthalamic nucleus (STN) deep brain stimulation (DBS) surgery on cognitive function in patients with advanced Parkinson's disease (PD). Methods: We examined 31 PD patients (Left STN n = 17; Right STN n = 14) who underwent unilateral subthalamic nucleus (STN) DBS as part of a NIH-sponsored randomized, cross-over, double-blind (ring vs directional) clinical trial. Outcome measures were tests of verbal fluency, auditory-verbal memory, and response inhibition. First, all participants were pooled together to study the effects of directional versus ring stimulation. Then, we stratified the groups by surgery hemisphere and studied the longitudinal changes in cognition post-unilateral STN DBS. Results: Relative to pre-DBS cognitive baseline performances, there were no group changes in cognition following unilateral DBS for either directional or ring stimulation. However, assessment of unilateral DBS by hemisphere revealed a different pattern. The left STN DBS group had lower verbal fluency than the right STN group ( Conclusions: Directional and ring DBS did not differentially or adversely affect cognition over time. Regarding hemisphere effects, verbal fluency decline was observed in those who received left STN DBS, along with the left and right STN DBS declines in delayed memory. The left STN DBS verbal fluency decrement is consistent with prior bilateral DBS research, likely reflecting disruption of the basal-ganglia-thalamocortical network connecting STN and inferior frontal gyrus. Interestingly, we found an improvement in verbal fluency and response inhibition following right STN DBS. It is possible that unilateral STN DBS, particularly in the right hemisphere, may mitigate cognitive decline.

Indexed as

cognitionDeep brain stimulationdirection stimulationneuropsychological assessmentParkinson’s diseasesubthalamic nucleus

Identifiers

PMID36909562
PMCPMC10002774
OpenAlexW4323038149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.