Evidence map›Paper›PMID 36909559›Full record

ArticlebioRxiv : the preprint server for biology2023

Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice.

Rachel Grazda, Allison N Seyfried, Krishna Rao Maddipatti, Gabrielle Fredman, Katherine C MacNamara

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rachel GrazdaDepartment of Immunology and Microbiology, Albany Medical College, Albany, New York, USA.
Allison N SeyfriedDepartment of Immunology and Microbiology, Albany Medical College, Albany, New York, USA.
Krishna Rao MaddipattiDepartment of Pathology, Lipidomics Core Facility, Wayne State University, Detroit, Michigan, USA.
Gabrielle FredmanDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.
Katherine C MacNamaraDepartment of Immunology and Microbiology, Albany Medical College, Albany, New York, USA.
Albany Medical Center Hospital · USInstitute for Clinical Pharmacodynamics (United States) · USWayne State University · US

Funding

Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
NCRR NIH HHS S10 RR027926
6 · The paper itself

Abstract

Current treatments for severe aplastic anemia (SAA) rely on hematopoietic stem cell (HSC) transplantation and immunosuppressive therapies, however these treatments are not always effective. While immune-mediated destruction and inflammation are known drivers of SAA, the underlying mechanisms that lead to persistent inflammation are unknown. Using an established mouse model of SAA, we observed a significant increase in apoptotic cells within the bone marrow (BM) and demonstrate impaired efferocytosis in SAA mice, as compared to radiation controls. Single-cell transcriptomic analysis revealed heterogeneity among BM monocytes and unique populations emerged during SAA characterized by increased inflammatory signatures and significantly increased expression of

Identifiers

PMID36909559
PMCPMC10002513
OpenAlexW4320880020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.