Evidence map›Paper›PMID 36909544›Full record

ArticlebioRxiv : the preprint server for biology2023

Evolutionary diversification reveals distinct somatic versus germline cytoskeletal functions of the Arp2 branched actin nucleator protein.

Kaitlin A Stromberg, Tristan Spain, Sarah A Tomlin, Kristen Dominique Amarillo, Courtney M Schroeder

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kaitlin A StrombergDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX.
Tristan SpainDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX.
Sarah A TomlinDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Kristen Dominique AmarilloDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX.
Courtney M SchroederDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX.
Southwestern Medical Center · USHoward Hughes Medical Institute · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7M
Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Genetic Innovation of Cytoskeletal Proteins for Specialized Functions in the Male GermlineR00GM137038 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI SCHROEDER, COURTNEY MEGAN · 2022 to 2024
$747k
Genetic Innovation of Cytoskeletal Proteins for Specialized Functions in the Male GermlineK99GM137038 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SCHROEDER, COURTNEY MEGAN · 2020 to 2021
$200k
NCI NIH HHS P30 CA142543NIGMS NIH HHS K99 GM137038NIGMS NIH HHS R00 GM137038NIGMS NIH HHS R01 GM074108
6 · The paper itself

Abstract

Branched actin networks are critical in many cellular processes, including cell motility and division. Arp2, a protein within the 7-membered Arp2/3 complex, is responsible for generating branched actin. Given its essential roles, Arp2 evolves under stringent sequence conservation throughout eukaryotic evolution. We unexpectedly discovered recurrent evolutionary diversification of Arp2 in

Indexed as

actinArp2cytoskeletonevolutionfertilitysperm development

Identifiers

PMID36909544
PMCPMC10002617
OpenAlexW4322491382

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.