Evidence map›Paper›PMID 36909543›Full record

ArticlebioRxiv : the preprint server for biology2023

Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor.

Selma Piranej, Luona Zhang, Alisina Bazrafshan, Mariana Marin, Gregory B Melikyan, Khalid Salaita

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Selma PiranejDepartment of Chemistry, Emory University, Atlanta, GA 30322 (USA).
Luona ZhangDepartment of Chemistry, Emory University, Atlanta, GA 30322 (USA).
Alisina BazrafshanDepartment of Chemistry, Emory University, Atlanta, GA 30322 (USA).
Mariana MarinDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322 (USA).
Gregory B MelikyanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322 (USA).
Khalid SalaitaDepartment of Chemistry, Emory University, Atlanta, GA 30322 (USA).
Emory University · USGeorgia Institute of Technology · US

Funding

Rolosense: An innovative platform for automatic mobile phone readout of active SARS-CoV-2 particles (RADx-rad / SEED Administrative Supplement)U01AA029345 · NIAAA · EMORY UNIVERSITY · PI SALAITA, KHALID S. · 2021 to 2022
$1.4M
NIAAA NIH HHS U01 AA029345
6 · The paper itself

Abstract

Assays detecting viral infections play a significant role in limiting the spread of diseases such as SARS-CoV-2. Here we present Rolosense, a virus sensing platform that transduces the motion of synthetic DNA-based motors transporting 5-micron particles on RNA fuel chips. Motors and chips are modified with virus-binding aptamers that lead to stalling of motion. Therefore, motors perform a "mechanical test" of viral target and stall in the presence of whole virions which represents a unique mechanism of transduction distinct from conventional assays. Rolosense can detect SARS-CoV-2 spiked in artificial saliva and exhaled breath condensate with a sensitivity of 10

Identifiers

PMID36909543
PMCPMC10002644
OpenAlexW4322621056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.