Evidence map›Paper›PMID 36909527›Full record

ArticlebioRxiv : the preprint server for biology2023

Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids.

Jinlun Bai, David S Koos, Kayla Stepanian, Zachary Fouladian, Dominic W H Shayler, Jennifer G Aparicio, Scott E Fraser, Rex A Moats, David Cobrinik

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jinlun BaiThe Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
David S KoosThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Kayla StepanianThe Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Zachary FouladianThe Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Dominic W H ShaylerThe Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jennifer G AparicioThe Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Scott E FraserThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rex A MoatsThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
David CobrinikThe Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

Successive responses to oncogenic aberrations in retinoblastoma genesis.R01CA137124 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI David Cobrinik · 2011 to 2026
$6.3M
NCI NIH HHS R01 CA137124
6 · The paper itself

Abstract

Fluorescent reporter pluripotent stem cell (PSC) derived retinal organoids are powerful tools to investigate cell type-specific development and disease phenotypes. When combined with live imaging, they enable direct and repeated observation of cell behaviors within a developing retinal tissue. Here, we generated a human cone photoreceptor reporter line by CRISPR/Cas9 genome editing of WTC11-mTagRFPT-LMNB1 human induced pluripotent stem cells (iPSCs) by inserting enhanced green fluorescent protein (EGFP) coding sequences and a 2A self-cleaving peptide at the N-terminus of

Indexed as

cone photoreceptorCRISPRfluorescent reporterGNAT2iPSClive imagingretinal organoid

Identifiers

PMID36909527
PMCPMC10002746
OpenAlexW4323049085

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.