Evidence map›Paper›PMID 36909501›Full record

ArticlebioRxiv : the preprint server for biology2023

A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation.

Sierra Swords, Nuo Jia, Anne Norris, Jil Modi, Qian Cai, Barth D Grant

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sierra SwordsDepartment of Molecular Biology and Biochemistry Rutgers University, Piscataway, NJ USA, 08854.
Nuo JiaDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ USA, 08854.
Anne NorrisDepartment of Molecular Biology and Biochemistry Rutgers University, Piscataway, NJ USA, 08854.
Jil ModiDepartment of Molecular Biology and Biochemistry Rutgers University, Piscataway, NJ USA, 08854.
Qian CaiDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ USA, 08854.
Barth D GrantDepartment of Molecular Biology and Biochemistry Rutgers University, Piscataway, NJ USA, 08854.
Rutgers, The State University of New Jersey · US

Funding

The Role of Abnormal Inter-Organelle Communication in the Pathogenesis of TauopathyR01NS089737 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI Qian Cai · 2014 to 2026
$5.5M
Molecular regulation of endosome fission during endocytic recyclingR01GM135326 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Barth Demian Grant · 2020 to 2026
$2.6M
NIGMS NIH HHS R01 GM135326NINDS NIH HHS R01 NS089737
6 · The paper itself

Abstract

Autophagosomes fuse with lysosomes, forming autolysosomes that degrade engulfed cargo. To maintain lysosomal capacity, autolysosome reformation (ALR) must regenerate lysosomes from autolysosomes using a membrane tubule-based process. Maintaining lysosomal capacity is required to maintain proteostasis and cellular health, especially in neurons where lysosomal dysfunction has been repeatedly implicated in neurodegenerative disease. Cell biological studies have linked the DNA-J domain Hsc70 co-chaperone RME-8/DNAJC13 to endosomal coat protein regulation, while human genetics studies have linked RME-8/DNAJC13 to neurological disease, including Parkinsonism and Essential Tremor. We report new analysis of the requirements for the RME-8/DNAJC13 protein in neurons, focusing on

Identifiers

PMID36909501
PMCPMC10002637
OpenAlexW4322626132

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read33
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.