ArticleResearch square2023
An Optrode Array for Spatiotemporally Precise Large-Scale Optogenetic Stimulation of Deep Cortical Layers in Non-human Primates.
Alessandra Angelucci, Andrew Clark, Alexander Ingold, Christopher Reiche, Donald Cundy, Justin Balsor, Frederick Federer, Niall McAlinden, Yunzhou Cheng, John Rolston and 4 more
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In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors at 4 institutions in 2 countries.
Alessandra AngelucciMoran Eye Institute, University of Utah Health.
Andrew ClarkMoran Eye Institute, University of Utah Health.
Alexander IngoldMoran Eye Institute, University of Utah Health.
Donald CundyMoran Eye Institute, University of Utah Health.
Justin BalsorMoran Eye Institute, University of Utah Health.
Frederick FedererMoran Eye Institute, University of Utah Health.
Niall McAlindenUniversity of Strathclyde.
Yunzhou ChengUniversity of Strathclyde.
John RolstonBrigham & Women's Hospital and Harvard Medical School.
Loren RiethWest Virginia University.
Martin DawsonUniversity of Strathclyde.
Keith MathiesonUniversity of Strathclyde.
Steve BlairUniversity of Utah.
University of Utah · USUniversity of Strathclyde · GBBrigham and Women's Hospital · USWest Virginia University · US
Funding
University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2005 to 2026
$14.6MAnatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responsesR01EY026812 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ANGELUCCI, ALESSANDRA · 2016 to 2025
$4.7MParallel pathways in visual cortex: functional connectivity of output pathways from area V1 to area V2R01EY019743 · NEI · UNIVERSITY OF UTAH · PI ANGELUCCI, ALESSANDRA · 2009 to 2020
$4.2MConnectivity and function of inhibitory neurons in the primate visual cortexR01EY031959 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Alessandra Angelucci · 2020 to 2026
$3.0MDevelopment of an integrated array for simultaneous optogenetic stimulation and electrical recording to study cortical circuit function in the non-human primate brainU01NS099702 · NINDS · UNIVERSITY OF UTAH · PI ANGELUCCI, ALESSANDRA, BLAIR, STEVEN M · 2016 to 2018
$2.4MVision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3MNEI NIH HHS P30 EY014800NEI NIH HHS R01 EY019743NEI NIH HHS R01 EY026812NEI NIH HHS R01 EY031959NEI NIH HHS T32 EY024234NINDS NIH HHS U01 NS099702
6 · The paper itselfAbstract
Optogenetics has transformed studies of neural circuit function, but remains challenging to apply in non-human primates (NHPs). A major challenge is delivering intense and spatially precise patterned photostimulation across large volumes in deep tissue. Here, we have developed and validated the Utah Optrode Array (UOA) to meet this critical need. The UOA is a 10×10 glass waveguide array bonded to an electrically-addressable μLED array.
Indexed as
AAVcFoscurrent source densityfeedbackmacaquemulti-channel electrophysiologyneocortexOptogenetics
Identifiers
PMID36909489
PMCPMC10002840
OpenAlexW4322622786
What OpenQuestion holds
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LicenceCC BY
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