ArticlebioRxiv : the preprint server for biology2023
Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human Na
Khoa Ngo, Diego Lopez Mateos, Yanxiao Han, Kyle C Rouen, Surl-Hee Ahn, Heike Wulff, Colleen E Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Khoa NgoBiophysics Graduate Group, University of California, Davis.
Diego Lopez MateosBiophysics Graduate Group, University of California, Davis.
Yanxiao HanDepartment of Physiology and Membrane Biology, University of California, Davis.
Kyle C RouenBiophysics Graduate Group, University of California, Davis.
Surl-Hee AhnDepartment of Chemical Engineering, University of California, Davis.
Heike WulffDepartment of Pharmacology, University of California, Davis.
Colleen E ClancyDepartment of Physiology and Membrane Biology, University of California, Davis.
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California, Davis.
Igor VorobyovDepartment of Physiology and Membrane Biology, University of California, Davis.
Funding
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1MDevelopment of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7MIn silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7MPredictive multiscale in silico cardio-pharmacologyU01HL126273 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E · 2015 to 2019
$3.8MBreakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0MMulti-Scale Modeling of Vascular Signaling UnitsR01HL152681 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2020 to 2023
$2.4MUC Davis Training Program in Chemical BiologyT32GM136597 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHEILA Sue DAVID, Marie C. Heffern · 2021 to 2026
$1.7MNHLBI NIH HHS R01 HL128537NHLBI NIH HHS R01 HL152681NHLBI NIH HHS T32 HL086350NHLBI NIH HHS U01 HL126273NIGMS NIH HHS R01 GM116961NIGMS NIH HHS T32 GM136597NIH HHS OT2 OD026580
6 · The paper itselfAbstract
Human voltage-gated sodium (hNa
Indexed as
molecular dockingmolecular dynamics simulationpeptide toxinRosetta structural modelingVoltage-gated sodium channel
Identifiers
PMID36909474
PMCPMC10002706
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