Evidence map›Paper›PMID 36909471›Full record

ArticlebioRxiv : the preprint server for biology2023

Widespread post-transcriptional regulation of co-transmission.

Nannan Chen, Yunpeng Zhang, Emmanuel J Rivera-Rodriguez, Albert D Yu, Michael Hobin, Michael Rosbash, Leslie C Griffith

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nannan ChenDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Yunpeng ZhangDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Emmanuel J Rivera-RodriguezDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Albert D YuDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Michael HobinDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Michael RosbashDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Leslie C GriffithDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Brandeis University · USHoward Hughes Medical Institute · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Regulation of sleep by microRNAsP01NS090994 · NINDS · HARVARD MEDICAL SCHOOL · PI DAVIS, RONALD L · 2016 to 2020
$5.7M
Genetic tools for visualization of co-transmission in identified neuronsR21NS096414 · NINDS · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2016 to 2017
$447k
Unraveling miR-190 and its Role in Sleep in Drosophila melanogasterF31NS110273 · NINDS · BRANDEIS UNIVERSITY · PI RIVERA-RODRIGUEZ, EMMANUEL J. · 2019 to 2021
$63k
NIH HHS P40 OD018537NINDS NIH HHS F31 NS110273NINDS NIH HHS P01 NS090994NINDS NIH HHS R21 NS096414
6 · The paper itself

Abstract

While neurotransmitter identity was once considered singular and immutable for mature neurons, it is now appreciated that one neuron can release multiple neuroactive substances (co-transmission) whose identities can even change over time. To explore the mechanisms that tune the suite of transmitters a neuron releases, we developed transcriptional and translational reporters for cholinergic, glutamatergic, and GABAergic signaling in One-Sentence Summary: Cholinergic co-transmission in large populations of glutamatergic and GABAergic neurons in the

Identifiers

PMID36909471
PMCPMC10002718
OpenAlexW4323075878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.