ArticlebioRxiv : the preprint server for biology2023
Traumatic brain injury-induced fear generalization in mice involves hippocampal memory trace dysfunction and is alleviated by (
Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors at 9 institutions in 1 country.
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Abstract
introductionTraumatic brain injury (TBI) is a debilitating neurological disorder caused by an impact to the head by an outside force. TBI results in persistent cognitive impairments, including fear generalization, the inability to distinguish between aversive and neutral stimuli. The mechanisms underlying fear generalization have not been fully elucidated, and there are no targeted therapeutics to alleviate this symptom of TBI.
methodsTo identify the neural ensembles mediating fear generalization, we utilized the ArcCreER
resultsTBI mice exhibited increased fear generalization when compared with sham mice. This behavioral phenotype was paralleled by altered memory traces in the DG, CA3, and amygdala, but not by alterations in inflammation or sleep. In TBI mice, (
conclusionsThese data show that TBI induces fear generalization by altering fear memory traces, and that this deficit can be improved with a single injection of (
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