ArticlemedRxiv : the preprint server for health sciences2023
Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with
Sangeetha Kandoi, Cassandra Martinez, Kevin Xu Chen, L Vinod K Reddy, Miika Mehine, Brian C Mansfield, Jacque L Duncan, Deepak A Lamba
Open access · greenAbstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors at 3 institutions in 2 countries.
Sangeetha KandoiDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Cassandra MartinezDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Kevin Xu ChenEli and Edythe Broad Center of Regeneration Medicine & Stem Cell Research, University of California San Francisco, CA, USA.
L Vinod K ReddyDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Miika MehineBlueprint Genetics, Helsinki, Finland.
Brian C MansfieldSection on Cellular Differentiation, Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD USA.
Jacque L DuncanDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Deepak A LambaDepartment of Ophthalmology, University of California San Francisco, CA, USA.
University of California, San Francisco · USBlueprint Genetics (Finland) · FINational Institutes of Health · US
Funding
Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8MPREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7MDeveloping Cone-Dominant Retinal Disease Models as a Resource for Translational Vision ResearchU24EY029891 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI CARROLL, JOSEPH, DUNCAN, JACQUE LYNNE · 2018 to 2022
$6.6MMechanistic analysis and allellic genome editing of iPSC-derived dominant LCA modelR01EY032197 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 2021 to 2025
$2.5MNEI NIH HHS P30 EY002162NEI NIH HHS R01 EY032197NEI NIH HHS U24 EY029891NICHD NIH HHS T32 HD007470
6 · The paper itselfAbstract
Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (
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PMID36909455
PMCPMC10002783
OpenAlexW4323074609
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