ArticleFrontiers in endocrinology2023
Visceral fat correlates with insulin secretion and sensitivity independent of BMI and subcutaneous fat in Chinese with type 2 diabetes.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 37 citations in OpenAlex.
- Feasibility and Preliminary Effects of a 5-Day Fasting-Mimicking Diet in Asian Americans With Prediabetes: A Pilot Study.Diabetes, obesity & metabolism · 2026Article
- Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife.Journal of Alzheimer's disease : JAD · 2026Article
- Computed Tomography-Derived visceral fat area is associated with increased risk of kidney stone recurrence.Urolithiasis · 2026Article
- Central obesity and glycaemic control in newly diagnosed type 2 diabetes mellitus patients: evidence from Uzbekistan.BMC endocrine disorders · 2026Observational
- Higher visceral fat area is inversely associated with ketosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Effectiveness of metabolic management centers online tools in patients with type 2 diabetes.Annals of medicine · 2025Article
- Prevalence and determinants of insulin resistance among middle-aged adults in rural northern Ghana: an Awi-Gen cross-sectional study.BMC public health · 2025Article
- Association of the skeletal muscle mass to visceral fat area ratio with metabolically healthy obesity and metabolically unhealthy non-obesity: a cross-sectional study based on NHANES 2011-2018.Lipids in health and disease · 2025Article
- Effect of Visceral Adipose Tissue on Major Depressive Disorder: A Mendelian Randomisation Research.Actas espanolas de psiquiatria · 2025Article
- Association between visceral fat area and heart rate variability in high altitude migrants with OSA: the mediating effect of insulin resistance.Lipids in health and disease · 2025Article
- Article
- A Body Shape Index (ABSI) as a risk factor for all-cause mortality among US adults with type 2 diabetes: evidence from the NHANES 1999-2018.Journal of diabetes and metabolic disorders · 2025Article
- Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals.Diabetology & metabolic syndrome · 2025Article
- Impact of Ketogenic and Mediterranean Diets on Gut Microbiota Profile and Clinical Outcomes in Drug-Naïve Patients with Diabesity: A 12-Month Pilot Study.Metabolites · 2025Article
- Body Roundness Index and Risk of Gestational Diabetes Mellitus in Women of Reproductive Age: NHANES 2007-2018.International journal of women's health · 2025Article
- The association between obesity-related indicators and uncontrolled diabetes mellitus in the elderly: a community-based study in China.Frontiers in medicine · 2025Article
- Visceral obesity augments prescription use: An analysis of the cross-sectional study of NHANES 2011-2018.PloS one · 2025Article
- Relationship of the metabolic score for insulin resistance and the new-onset hypertension: Evidence from CHARLS.PloS one · 2025Article
- The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with early onset type 2 diabetes with NAFLD: a cross-sectional study in China.Frontiers in nutrition · 2025Article
- Associations between dynamic change of Chinese visceral adiposity index and hypertensive co-morbidities in the middle-aged and elderly population: a Chinese prospective cohort study.Frontiers in nutrition · 2025Article
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6 authors at 2 institutions in 1 country.
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Abstract
Aim: Clinical heterogeneity exists in overall obesity and abdominal obesity in terms of insulin secretion and sensitivity. Further, the impact of visceral fat (VF) on the first- and second-phase insulin secretion (FPIS and SPIS) is controversial. We aim to investigate insulin secretion and sensitivity in Chinese patients with T2DM according to different BMI and VF levels. Methods: This study enrolled 300 participants. A dual bioelectrical impedance analyzer was used to assess the visceral and subcutaneous fat area (VFA and SFA). VF levels were categorized as normal or high, with the cutoff value of 100 cm Results: Participants were categorized into four groups: normal weight-normal VF, normal weight-high VF, overweight/obese-normal VF and overweight/obese-high VF. Multivariate linear regression showed that both VFA and SFA were correlated with FPIS, HOMA2-IR and Gutt-ISI after controlling for gender and diabetes duration. After further adjustment for BMI and VFA, some associations of SFA with insulin secretion and sensitivity disappeared. After adjustment for gender, diabetes duration, BMI and SFA, VFA was positively correlated with FPIS, SPIS and HOMA2-IR. Subjects with overweight/obese-high VF were more likely to have higher FPIS, HOMA2-IR and lower Gutt-ISI (all Conclusion: VF affects both FPIS and SPIS, and worsens insulin sensitivity independent of BMI and subcutaneous fat in Chinese patients with T2DM. Clinical trial registration: http://www.chictr.org.cn, identifier ChiCTR2200062884.
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