Evidence map›Paper›PMID 36909187›Full record

ArticleFrontiers in pharmacology2023

Hypoxia-ameliorated photothermal manganese dioxide nanoplatform for reversing doxorubicin resistance.

Zhenzhen Chen, Zhihong Liu, Qian Zhang, Sheng Huang, Zaizhong Zhang, Xianquan Feng, Lingjun Zeng, Ding Lin, Lie Wang, Hongtao Song

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenzhen ChenDepartment of General Surgery, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.
Zhihong LiuDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.
Qian ZhangCollege of Pharmacy, Fujian Medical University, Fuzhou, China.
Sheng HuangDepartment of General Surgery, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.
Zaizhong ZhangDepartment of General Surgery, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.
Xianquan FengCollege of Pharmacy, Fujian Medical University, Fuzhou, China.
Lingjun ZengDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.
Ding LinDepartment of Pharmacy, Jiaxing Maternal and Child Healthcare Hospital, Affiliated Hospital of Jiaxing University, Jiaxing, China.
Lie WangDepartment of General Surgery, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.
Hongtao SongDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug resistance is a huge hurdle in tumor therapy. Tumor hypoxia contributes to chemotherapy resistance by inducing the hypoxia-inducible factor-1α (HIF-1α) pathway. To reduce tumor hypoxia, novel approaches have been devised, providing significant importance to reverse therapeutic resistance and improve the effectiveness of antitumor therapies. Herein, the nanosystem of bovine serum albumin (BSA)-templated manganese dioxide (MnO

Indexed as

doxorubicindrug resistancehypoxiaphotothermal-manganese dioxidetumor microenvironment response

Identifiers

PMID36909187
PMCPMC9998484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.