Evidence map›Paper›PMID 36908969›Full record

ArticleChemical science2023

Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(sp

Longbo Li, Bianca Matsuo, Guillaume Levitre, Edward J McClain, Eric A Voight, Erika A Crane, Gary A Molander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Longbo LiDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania 231 South 34th Street Philadelphia Pennsylvania 19104-6323 USA gmolandr@sas.upenn.edu.ORCID https://orcid.org/0000-0002-6806-4778
Bianca MatsuoDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania 231 South 34th Street Philadelphia Pennsylvania 19104-6323 USA gmolandr@sas.upenn.edu.ORCID https://orcid.org/0000-0001-7311-0428
Guillaume LevitreDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania 231 South 34th Street Philadelphia Pennsylvania 19104-6323 USA gmolandr@sas.upenn.edu.
Edward J McClainDrug Discovery Science & Technology, Discovery Research & Development, AbbVie, Inc., 1 North Waukegan Rd North Chicago Illinois 60064-1802 USA.
Eric A VoightDrug Discovery Science & Technology, Discovery Research & Development, AbbVie, Inc., 1 North Waukegan Rd North Chicago Illinois 60064-1802 USA.ORCID https://orcid.org/0000-0002-9542-5356
Erika A CraneDrug Hunter, Inc. 13203 SE 172nd Ave, Suite 166 PMB 2019 Happy Valley Oregon 97086 USA erika@drughunter.com.
Gary A MolanderDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania 231 South 34th Street Philadelphia Pennsylvania 19104-6323 USA gmolandr@sas.upenn.edu.ORCID https://orcid.org/0000-0002-9114-5584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-encoded library (DEL) screens have significantly impacted new lead compound identification efforts within drug discovery. An advantage of DELs compared to traditional screening methods is that an exponentially broader chemical space can be effectively screened using only nmol quantities of billions of DNA-tagged, drug-like molecules. The synthesis of DELs containing diverse, sp

Identifiers

PMID36908969
PMCPMC9993886

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.