ArticleChemical science2023
Simple and scalable electrosynthesis of 1
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Electrochemical Synthesis of 1,2-SubstitutedOrganic letters · 2026Article
- Diamond Chemistry: Advances and Perspectives.Angewandte Chemie (International ed. in English) · 2025Review
- Simple and versatile electrochemical synthesis of highly substituted 2,1-benzisoxazoles.Organic & biomolecular chemistry · 2025Article
- Highly Selective Electrosynthesis of 1Organic process research & development · 2024Article
- Simple electrochemical synthesis of cyclic hydroxamic acids by reduction of nitroarenes.Chemical communications (Cambridge, England) · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cathodic synthesis provides sustainable access to 1-hydroxy- and 1-oxy-quinazolin-4-ones from easily accessible nitro starting materials. Mild reaction conditions, inexpensive and reusable carbon-based electrode materials, an undivided electrochemical setup, and constant current conditions characterise this method. Sulphuric acid is used as a simple supporting electrolyte as well as a catalyst for cyclisation. The broad applicability of this protocol is demonstrated in 27 differently substituted derivatives in high yields of up to 92%. Moreover, mechanistic studies based on cyclic voltammetry measurements highlight a selective reduction of the nitro substrate to hydroxylamine as a key step. The relevance for preparative applications is demonstrated by a 100-fold scale-up for gram-scale electrolysis.
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Registered trials
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