ArticleFrontiers in nutrition2023
Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.
Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Targeting Gut Dysbiosis and Short-Chain Fatty Acid Deficiency in Chronic Eczema: A Case Report.Integrative medicine (Encinitas, Calif.) · 2026Article
- Neuroimmune Genetic Overlap Between Chronic Pruritic Skin Diseases and Major Depressive Disorder: Insights from Cross-Trait GWAS Analysis.Clinical, cosmetic and investigational dermatology · 2026Article
- Non-invasive detection of pediatric atopic dermatitis based on fecal microbiota and metabolite profiles: a diagnostic approach.Frontiers in immunology · 2026Article
- Mendelian randomization studies in atopic dermatitis: causal insights across omics layers.Frontiers in immunology · 2026Review
- Dietary approaches in dermatological disorders: mechanisms and clinical relevance.Postepy dermatologii i alergologii · 2026Review
- Integrative multi-omics identification and functional validation of potential targets linking metabolism-immune-colorectal cancer causal pathway.Frontiers in immunology · 2025Article
- Review
- Deficit of Omega-3 Fatty Acids in Acne Patients-A Cross-Sectional Pilot Study in a German Cohort.Life (Basel, Switzerland) · 2024Article
- The Impact of Immune Cells, Metabolites, Inflammatory Factors, and Circulating Proteins on Atopic Dermatitis: Insights from a Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2024Article
- Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in autoimmune rheumatic diseases: a brief research report from a Mendelian randomization study.Frontiers in nutrition · 2024Article
- The association between the dietary inflammatory index and allergic rhinitis: a case-control study.Frontiers in nutrition · 2024Article
- Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review.Nutrients · 2023Review
- Integrative polygenic analysis of the protective effects of fatty acid metabolism on disease as modified by obesity.Frontiers in nutrition · 2023Article
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Authors and funding
5 authors.
Funding
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Abstract
Background: Some evidence suggests abnormalities in fatty acids in patients with atopic dermatitis (AD), and benefits of supplementation with these fatty acids have been reported. However, there is still substantial controversy on the correlation between fatty acids and AD. Therefore, the aim of this study was to determine whether fatty acid levels are causally related to AD using a Mendelian randomization approach. Methods: We evaluated the data about the fatty acids levels and AD with various methods from Genome-Wide Association Study (GWAS). GWAS results were available both from European ancestry. Mendelian randomization methods were used to analysis the casual inference of fatty acids on AD. MR Egger and MR-PRESSO were used to determine pleiotropy and heterogeneity. Further analysis was conducted using instruments associated with the Results: Mendelian randomization (MR) analysis suggests that n-3 fatty acid levels are associated with a lower risk of AD (n-3 OR Conclusion: Our studies suggest that n-3 fatty acids may reduce the risk of AD. Risk prediction tools based on n-3 fatty acid levels may be valuable methods for improving AD screening and primary prevention. To reduce the risk of AD, individuals could enhance n-3 fatty acids intake through supplement or diet.
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