ArticleAging brain2022
Capillary function progressively deteriorates in prodromal Alzheimer's disease: A longitudinal MRI perfusion study.
Article in Aging brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Treatment of Clinically Diagnosed Alzheimer's Disease by External Counterpulsation A Randomized Clinical Trial.American journal of Alzheimer's disease and other dementiasTrial
- Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis.The Journal of physiology · 2026Review
- Cerebral oxygen extraction fraction as an emerging imaging biomarker in mild cognitive impairment and dementia.Dementia & neuropsychologia · 2026Review
- The vascular contribution to cognitive decline in ageing and dementia.Nature reviews. Neuroscience · 2025Review
- Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice.Nature communications · 2025Article
- Venous arterial spin labeling MRI signal is associated with oxygen supply-independent reduction in cerebral oxygen extraction in typically aging older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebral microvascular changes in healthy carriers of the APOE-ɛ4 Alzheimer's disease risk gene.PNAS nexus · 2024Article
- Cognitive decline, Aβ pathology, and blood-brain barrier function in aged 5xFAD mice.Fluids and barriers of the CNS · 2024Article
- Development of capillary dysfunction in Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
- Small vessel disease burden and functional brain connectivity in mild cognitive impairment.Cerebral circulation - cognition and behavior · 2024Article
- Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
9 authors.
Funding
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Abstract
Cardiovascular risk factors are associated with the development of Alzheimer's disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD.
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