ArticleAging brain2022
Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer's disease.
Article in Aging brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.Biopsychosocial science and medicine · 2026Article
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer's disease copathologies.NPJ Parkinson's disease · 2025Article
- White matter microstructure statistically mediates associations between circadian rest/activity rhythms and cognition in older adults.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Intra-voxel angular dispersion of fibers in corpus callosum decreases with healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognition.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease.Molecular psychiatry · 2024Article
- Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status.Nature communications · 2024Article
- Brain elastography in aging relates to fluid/solid trendlines.Physics in medicine and biology · 2024Article
- Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies.NPJ Parkinson's disease · 2024Article
- Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline.Frontiers in neurology · 2024Article
- Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health.Cerebral circulation - cognition and behavior · 2024Article
- Purpose in life as a resilience factor for brain health: diffusion MRI findings from the Midlife in the U.S. study.Frontiers in psychiatry · 2024Article
- Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping.Aging and disease · 2023Article
- The use of neuroimaging techniques in the early and differential diagnosis of dementia.Molecular psychiatry · 2023Review
- C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter.Frontiers in neurology · 2023Article
- Impact of asthma on the brain: evidence from diffusion MRI, CSF biomarkers and cognitive decline.Brain communications · 2023Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal to be divided into multiple water compartments and derive measures for orientation dispersion index (ODI), neurite density index (NDI) and volume fraction of isotropic diffusion compartment (FISO). This study aimed to investigate which diffusion metric-fractional anisotropy (FA), mean diffusivity (MD), NDI, ODI, or FISO-is most influenced by aging and reflects cognitive function in a population of healthy older adults at risk for Alzheimer's disease (AD). Age was significantly associated with all but one diffusion parameters and regions of interest. NDI and MD in the cingulate region adjacent to the cingulate cortex showed a significant association with a composite measure of Executive Function and was proven to partially mediate the relationship between aging and Executive Function decline. These results suggest that both DTI and NODDI parameters are sensitive to age-related differences in white matter regions vulnerable to aging, particularly among older adults at risk for AD.
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