Evidence map›Paper›PMID 36908892›Full record

ArticleAging brain2022

Evaluating associations of RNFL thickness and multifocal VEP with cognitive assessment and brain MRI volumes in older adults: Optic nerve decline and cognitive change (ONDCC) initiative.

Ting Shen, Samran Sheriff, Yuyi You, Jiyang Jiang, Angela Schulz, Heather Francis, Mehdi Mirzaei, Danit Saks, Nitin Chitranshi, Veer Gupta and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. The Association ofJournal of clinical medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ting ShenDepartment of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Samran SheriffMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Yuyi YouMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Jiyang JiangCentre for Healthy Brain Ageing and the Neuropsychiatric Institute, University of New South Wales, Sydney, NSW, Australia.
Angela SchulzMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Heather FrancisMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Mehdi MirzaeiMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Danit SaksMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Nitin ChitranshiMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Veer GuptaFaculty of Health, Deakin University, VIC, Australia.
Maria Fiatarone SinghThe University of Sydney, Sydney, NSW, Australia.
Alexander KlistornerMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Wei WenCentre for Healthy Brain Ageing and the Neuropsychiatric Institute, University of New South Wales, Sydney, NSW, Australia.
Perminder SachdevCentre for Healthy Brain Ageing and the Neuropsychiatric Institute, University of New South Wales, Sydney, NSW, Australia.
Vivek K GuptaMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Stuart L GrahamMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To examine the relationships of retinal structural (optical coherence tomography) and visual functional (multifocal visual evoked potentials, mfVEP) indices with neuropsychological and brain structural measurements in healthy older subjects. 95 participants (mean (SD) age 68.1 (9.0)) years were recruited in the Optic Nerve Decline and Cognitive Change (ONDCC) study in this observational clinical investigation. OCT was conducted for retinal nerve fibre layer (RNFL) and mfVEP for amplitude and latency measurements. Participants undertook neuropsychological tests for cognitive performance and MRI for volumetric evaluation of various brain regions. Generalised estimating equation models were used for association analysis (p < 0.05). The brain volumetric measures including total grey matter (GM), cortex, thalamus, hippocampal and fourth ventricular volumes were significantly associated with global and sectoral RNFL. RNFL thickness correlated with delayed recalls of California verbal learning test (CVLT) and Rey complex figure test (RCFT). The mfVEP amplitudes associated with cerebral white matter (WM) and cingulate GM volumes in MRI and CVLT, RCFT and trail making test outcomes. A significant association of mfVEP latency with logical memory delayed recall and thalamus volume was also observed. Our results suggested significant association of specific RNFL and mfVEP measures with distinctive brain region volumes and cognitive tests reflecting performance in memory, visuospatial and executive functional domains. These findings indicate that the mfVEP and RNFL measurements may parallel brain structural and neuropsychological measures in the older population.

Indexed as

AgingCognitionMemorymfVEPMRIRNFL

Identifiers

PMID36908892
PMCPMC9997126

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.