Evidence map›Paper›PMID 36908875›Full record

ArticleAging brain2022

Brain and cognitive ageing: The present, and some predictions (…about the future).

Simon R Cox, Ian J Deary

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  8. Lessons we learned from the Lothian Birth Cohorts of 1921 and 1936.Genomic psychiatry : advancing science from genes to society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Simon R CoxLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Ian J DearyLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
University of Edinburgh · GB

Funding

Evaluating Longitudinal Changes in the Human Structural Connectome in Relation to Cognitive AgingR01AG054628 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2017 to 2021
$2.7M
Medical Research Council G0700704Medical Research Council G1001245NIA NIH HHS R01 AG054628Wellcome Trust
6 · The paper itself

Abstract

Experiencing decline in one's cognitive abilities is among the most feared aspects of growing old [53]. Age-related cognitive decline carries a huge personal, societal, and financial cost both in pathological ageing (such as dementias) and also within the non-clinical majority of the population. A projected 152 million people worldwide will suffer from dementia by 2050 [3]. The early stages of cognitive decline are much more prevalent than dementia, and can still impose serious limitations of performance on everyday activities, independence, and quality of life in older age [5], [60], [80]. Cognitive decline also predicts poorer health, adherence to medical regimens, and financial decision-making, and can herald dementia, illness, and death [6], [40]. Of course, when seeking to understand why some people experience more severe cognitive ageing than others, researchers have turned to the organ of thinking for clues about the nature, possible mechanisms, and determinants that might underpin more and less successful cognitive agers. However, that organ is relatively inaccessible, a limitation partly alleviated by advances in neuroimaging. Here we discuss lessons for cognitive and brain ageing that have come from neuroimaging research (especially structural brain imaging), what neuroimaging still has left to teach us, and our views on possible ways forward in this multidisciplinary field.

Indexed as

Brain ageingDiffusion MRIEpidemiologyLongitudinal studiesReviewStructural MRI

Identifiers

PMID36908875
PMCPMC9997131
OpenAlexW4214484730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.