Evidence map›Paper›PMID 36908807›Full record

ArticleFrontiers in immunology2022

Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor

Maryam Mehri, Reza Gheitasi, Roghayeh Pourbagher, Mohammad Ranaee, Kosar Nayeri, Seyed Mostafa Rahimi, Hamid Reza Khorasani, Hadi Hossein-Nattaj, Davood Sabour, Haleh Akhavan-Niaki and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Maryam MehriStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.
Reza GheitasiInstitute of Infectious Diseases and Infection Control, Jena University Hospital/Friedrich Schiller University, Jena, Germany.
Roghayeh PourbagherStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.
Mohammad RanaeeDepartment of Pathology, School of Medicine, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Kosar NayeriStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.
Seyed Mostafa RahimiCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Hamid Reza KhorasaniDepartment of Cancer Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research (ACECR), Babol, Iran.
Hadi Hossein-NattajImmunology Department, Mazandaran University of Medical Sciences, Sari, Iran.
Davood SabourDepartment of Cancer Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research (ACECR), Babol, Iran.
Haleh Akhavan-NiakiCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Sadegh FattahiNorth Research Center, Pasteur Institute of Iran, Amol, Iran.
Behnam KalaliDepartment of Medicine II, Klinikum Grosshadern, Ludwig Maximilian University (LMU) University, Munich, Germany.
Amrollah MostafazadehCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Babol University of Medical Sciences · IRRoyan Institute · IRFriedrich Schiller University Jena · DELudwig-Maximilians-Universität München · DEMazandaran University of Medical Sciences · IRPasteur Institute of Iran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The microenvironment of solid tumors such as breast cancer is heterogeneous and complex, containing different types of cell, namely, cancer stem cells and immune cells. We previously reported the immunoregulatory behavior of the human immune cell in a solid tumor microenvironment-like culture under serum starvation stress for 96 h. Here, we examined the effect of this culture-derived solution on breast cancer development in rats. Method: Ninety-six-hour starved PBMCs supernatant (96 h-SPS) was collected after culturing human PBMCs for 96 h under serum starvation condition. Breast cancer stem cells, LA7 cell line, was used for Results: 96 h-SPS solution reduced the LA7 cell viability, proliferation, and migration and Conclusion: 96 h-SPS solution may help to prevent cancer stem cell mediated tumor development. This phenomenon could be mediated through direct cytotoxic effects, inhibition of cell proliferation and migration in association with reduction in

Indexed as

Breast NeoplasmsAnimalsFemaleGTP CyclohydrolaseKi-67 AntigenLeukocytes, MononuclearNecrosisNeoplastic Stem CellsRatsRats, Sprague-DawleyTandem Mass SpectrometryTumor MicroenvironmentGch1 protein, ratGTP CyclohydrolaseKi-67 Antigenadaptive immunitybreast cancer stem cellscancer developmentimmunohistochemistryLA7nano-LC-ESI-MS/MSserum starvation

Identifiers

PMID36908807
PMCPMC9996193
OpenAlexW4321595699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.