ArticleJournal of conservative dentistry : JCD
Cytotoxicity evaluation of Bio-C, CeraSeal, MTA - Fillapex, and AH Plus root canal sealers by microscopic and 3-(4, 5 dimethythiazol-2yl)-2, 5-diphenyltetrazolium bromide (MTT) assay.
Article in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Postoperative pain and quality of life after the use of different endodontic sealers in asymptomatic molars: a randomized clinical trial.Clinical oral investigations · 2026Trial
- Postoperative Pain After Root Canal Filling with Different Bioceramic Endodontic Sealers: A Double-Blind Randomized Clinical Pilot Trial.Healthcare (Basel, Switzerland) · 2026Article
- Effect of Iron Oxide Nanoparticle Incorporation on the Cytocompatibility and Antimicrobial Behavior of a Calcium Silicate-Based Endodontic Sealer.Biomedicines · 2026Article
- Cytocompatibility of calcium hydroxide medicament combined with cationic peptide - AnJournal of conservative dentistry and endodontics · 2026Article
- Histopathological evaluation of bone tissue response to endodontic sealers and gutta-percha using an intraosseous implantation model in Wistar rats.Journal of conservative dentistry and endodontics · 2026Article
- Influence of irrigating solutions on the hydration of calcium silicate-based dental biomaterials: AnJournal of conservative dentistry and endodontics · 2025Article
- Cytotoxicity of hydraulic cement dicalcium silicate mixture of eggshell calcium and rice husk silica on fibroblast cells.Journal of conservative dentistry and endodontics · 2025Article
- Could the sealer thickness affect the filling ability of bioceramic endodontic materials? Evaluation in a simulated physiological condition.Journal of conservative dentistry and endodontics · 2025Article
- Comparative evaluation of retreatability of three different bioceramic sealers using xylene in root canal retreatment - AnJournal of conservative dentistry and endodontics · 2025Article
- Evaluation of osteoconductivity and inflammatory response of a resin-based and a resin-free calcium silicate sealer: an in vivo study.Clinical oral investigations · 2025Article
- Evaluation of the Genotoxicity and Cytotoxicity of Bioceramic Endodontic Sealers in HepG2 and V79 Cell Lines: An In Vitro Study Using the Comet and Micronucleus Assays.Journal of functional biomaterials · 2025Article
- Comparative analysis of the inflammatory response of human gingival fibroblasts to NeoSEALER Flo and CeraSeal bioceramic sealers: an in vitro study.BMC oral health · 2025Article
- Review
- Article
- Comparative evaluation of cytotoxic effects of a new biomaterial nanohydroxyapatite-lactoferrin, nanohydroxyapatite, mineral trioxide aggregate, and calcium-enriched mixture on human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2025Article
- Impact of various endodontic sealers on HPDLF Cell viability and apoptosis.Scientific reports · 2024Article
- Comparative analysis of an epoxy resin-based and a premixed calcium silicate-based sealer's push-out bond strength with and without incorporation of chitosan nanoparticles: AnJournal of conservative dentistry and endodontics · 2024Article
- Biocompatibility, bioactivity and immunomodulatory properties of three calcium silicate-based sealers: an in vitro study on hPDLSCs.Clinical oral investigations · 2024Article
- Antimicrobial efficacy of calcium silicate-based bioceramic sealers againstJournal of conservative dentistry and endodontics · 2024Article
- Comparative evaluation of push-out bond strength and mode of failure of three different obturating materials: AnJournal of conservative dentistry and endodontics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The aim of this study was to compare the cytotoxic effect of calcium silicate-based Bio-C, CeraSeal, and mineral trioxide aggregate (MTA)-based (MTA-Fillapex) sealers to a widely used resin-based sealer (AH Plus) using 3-(4, 5 dimethythiazol-2yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and microscopic examination. Materials and Methods: A total of ( Results: Bio-C and CeraSeal showed a reduction in cytotoxicity from severe at 0 h to no cytotoxicity at 24 h and 7 day time period. AH Plus showed severe cytotoxicity at all time periods. MTA-Fillapex showed severe cytotoxicity at 0 h which decreased to moderate at 24 h and 7 days. The differences between groups were statistically significant ( Conclusions: The sealers with resin constituents (AH Plus and MTA-Fillapex) showed severe-to-moderate cytotoxicity at different time periods, whereas calcium silicate-based sealers (Bio-C and CeraSeal) were relatively biocompatible as their cytotoxicity decreased significantly from severe initially to noncytotoxic with time.
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What OpenQuestion holds
Registered trials
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