Evidence map›Paper›PMID 36908588›Full record

ArticleFrontiers in neurology2023

Effect of intravenous thrombolysis on core growth rate in patients with acute cerebral infarction.

Xueqi Wang, Hao Zhang, Qi Wang, Gang Li, Hao Shen, Yaping Xiao, Luran Xu, Yuming Long, Chen Chen, Zhengyu Huang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xueqi WangShanghai East Hospital, Tongji University, Shanghai, China.
Hao ZhangShanghai East Hospital, Tongji University, Shanghai, China.
Qi WangShanghai East Hospital, Tongji University, Shanghai, China.
Gang LiShanghai East Hospital, Tongji University, Shanghai, China.
Hao ShenShanghai East Hospital, Tongji University, Shanghai, China.
Yaping XiaoShanghai East Hospital, Tongji University, Shanghai, China.
Luran XuShanghai East Hospital, Tongji University, Shanghai, China.
Yuming LongShanghai East Hospital, Tongji University, Shanghai, China.
Chen ChenShanghai East Hospital, Tongji University, Shanghai, China.
Zhengyu HuangShanghai East Hospital, Tongji University, Shanghai, China.
Yue ZhangShanghai East Hospital, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate the effects of recombinant tissue plasminogen activator intravenous thrombolysis (IVT) on the core growth rate of acute ischemic stroke. Methods: Stroke patients with large vessel occlusion and non-recanalization from IVT treatment were retrospectively included in this study and divided into two groups: IVT and non-IVT. The core growth rate was estimated by the acute core volume on perfusion CT divided by the last known well time from stroke to CT perfusion. The primary endpoint was the core growth rate, the tissue outcome was 24 h-ASPECTS, and the clinical outcome was a 3-month modified Rankin score. Results: A total of 94 patients were included with 53 in the IVT group and 41 in the non-IVT group. There was no significant difference in age, gender, hypertension, diabetes, atrial fibrillation, acute NIHSS, and last known well time from stroke to CT perfusion acquisition between the two groups. The core growth rate in the IVT group was lower than that in the non-IVT group, which was statistically significant after multivariate adjustment (coefficient: -5.20, 95% CI= [-9.85, -0.56], Conclusion: Intravenous thrombolysis reduces the core growth rate in patients with AIS, especially those with poor collateral status.

Indexed as

acute ischemic strokecollateral circulationcore growth rateintravenous thrombolysislarge vessel occlusionreperfusiontherapy

Identifiers

PMID36908588
PMCPMC9996056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.