Evidence map›Paper›PMID 36908365›Full record

ArticleJournal of food science and technology2023

Enrichment of soy isoflavone extracts through macroporous resin for characterization of toxicity and estrogenic activities.

Thi Ngoc Thu Tran, Thi Minh Hanh Truong, Thi Dong Phuong Nguyen, Vung Xuan Bui, Do Thi Thao, Tran-van Luan, Kuan Shiong Khoo, Kit Wayne Chew, Pau Loke Show

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In one paragraph

Article in Journal of food science and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Thi Ngoc Thu TranThe University of Danang, University of Technology and Education, 48 Cao Thang St., Danang, 550 000 Vietnam.
Thi Minh Hanh TruongThe University of Danang, University of Science and Technology, 54 Nguyen Luong Bang St., Danang, 550 000 Vietnam.
Thi Dong Phuong NguyenThe University of Danang, University of Technology and Education, 48 Cao Thang St., Danang, 550 000 Vietnam.
Vung Xuan BuiThe University of Danang, University of Science and Education, 459 Ton Duc Thang St., Danang, 550 000 Vietnam.
Do Thi ThaoInstitute of Biotechnology (IBT), Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, 100000 Vietnam.
Tran-van LuanThe University of Danang, University of Science and Technology, 54 Nguyen Luong Bang St., Danang, 550 000 Vietnam.
Kuan Shiong KhooFaculty of Applied Sciences, UCSI University, UCSI Heights, 56000 Cheras, Kuala Lumpur, Malaysia.
Kit Wayne ChewSchool of Energy and Chemical Engineering, Xiamen University Malaysia, Jalan Sunsuria, Bandar Sunsuria, 43900 Sepang, Selangor Darul Ehsan Malaysia.
Pau Loke ShowDepartment of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan Malaysia.ORCID 0000-0002-0913-5409
University of Da Nang · VNUCSI University · MYVietnam Academy of Science and Technology · VNWenzhou University · CNXiamen University Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soy isoflavone extracts are widely researched for their distinctive potential in contributing to various functional foods. The research work focuses on testing the toxicity of purified soy isoflavone extracts in mice models. With an agreement of the animal ethics, acute toxicity is firstly used to screen the effects of test compounds in mice for therapeutic purposes. Moreover, tests were conducted on BALB/c for estrogen in vivo and MCF7 for in vitro, screening active protection of liver cells, lipid peroxidation and scavenging free radicals 2,2-diphenyl-1-picrylhydrazyl (DPPH). Genistin and daidzin were found to be the two major compounds accounting for 47% and 35% of total purified soy isoflavones. The acute toxicity test results exhibited no effect against physiological accretion of BALB/c after 7-day administration with the given dose of 10 g/kgBW. Moreover, modified E-screen assay on MCF7 cells proved that the estrogen of isoflavone extracts induces cell proliferation by 15% compared with other non-steroid culture techniques. Therefore, this research contributes to helping researchers apply soy isoflavones in functional food, to alleviate the difficulties in menopausal symptoms for women in the future. Supplementary Information: The online version contains supplementary material available at 10.1007/s13197-022-05491-4.

Indexed as

E-screen assayHepatoprotectionLipid peroxidationMouse acute toxicitySoy isoflavones

Identifiers

PMID36908365
PMCPMC9998774
OpenAlexW4288058112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.