Evidence map›Paper›PMID 36908304›Full record

ArticleInternational journal of pharmaceutics: X2023

Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections:

Sammar Fathy Elhabal, Shrouk A Ghaffar, Raghda Hager, Nahla A Elzohairy, Mohamed Mansour Khalifa, Passant M Mohie, Rania A Gad, Nasreen N Omar, Mohammed H Elkomy, Mohammad Ahmad Khasawneh and 1 more

Erratum issuedAbstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  16. Green Synthesis of Zinc Oxide Nanoparticles fromInternational journal of nanomedicine · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sammar Fathy ElhabalDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo 11571, Egypt.
Shrouk A GhaffarTactical Medical Department, Caduceus Lane Healthcare, Alexandria 21532, Egypt.
Raghda HagerDepartment of Medicinal Microbiology and Immunology, Faculty of Medicine King Salman International University, El-Tor, South Siniai, Egypt.
Nahla A ElzohairyAir Force Specialized Hospital, Cairo 19448, Egypt.
Mohamed Mansour KhalifaDepartment of Human Physiology, Faculty of Medicine, Cairo University, Egypt.
Passant M MohieDepartment of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria 21532, Egypt.
Rania A GadDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef (NUB), Beni-Suef, 62511, Egypt.
Nasreen N OmarDepartment of Biochemistry, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo 11571, Egypt.
Mohammed H ElkomyDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
Mohammad Ahmad KhasawnehDepartment of Chemistry, College of Science U.A.E. University, Al-Ain, P.O. Box 17551, United Arab Emirates.
Nashwa AbdelaalDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most prevalent conditions among ocular surgery and COVID-19 patients are fungal eye infections, which may cause inflammation and dry eye, and may cause ocular morbidity. Amphotericin-B eye drops are commonly used in the treatment of ocular fungal infections. Lactoferrin is an iron-binding glycoprotein with broad-spectrum antimicrobial activity and is used for the treatment of dry eye, conjunctivitis, and ocular inflammation. However, poor aqueous stability and excessive nasolacrimal duct draining impede these agens' efficiency. The aim of this study was to examine the effect of Amphotericin-B, as an antifungal against

Indexed as

A, aqueous phaseAMP, Amphotericin-BAmphotericin-BANOVA, Analysis of varianceAtomic force microscopy (AFM)BCS, Biopharmaceutical Classification SystemBLF, Bovine LactoferrinCandida albicansCD14, Cluster of differentiation 14CK, Creatine kinaseConfocal laser scanning microscopy (CLSM)DLS, dynamic light scatteringDMSO, dimethyl sulfoxideDraize testDSC, Differential scanning calorimetryEDC, ethyl-3-(3-dimethyl aminopropyl) carbodiimideEE%, Entrapment efficiencyFT-IR, Fourier transform infraredFT-IR, Fourier-transform infrared spectroscopyGRAS, Generally recognized as a safeHCE-2, human corneal epithelial cellsJ, steady-state fluxKp, permeability coefficientLactoferrinLPS, LipopolysaccharideMIC, minimum inhibitory concentrationNanoparticlesNCCLS, National Committee for Clinical Laboratory StandardsNHS, N-hydroxysuccinimideNPs, nanoparticlesO, organic phaseP188, Kolliphor®P188P407, Poloxamer 407PBS, Phosphate buffered saline solutionPDI, Polydispersity indexPEG, polyethylene glycolPEI, poly-ethylene iminePLGA, Poly (lactic-co-glycolic acid)PS, Particle sizeQ24, amount penetrated after 24 hQR, Quantity retainedREC, rules of the Study Ethics CommitteeSD, Standard deviationsSEM, Scanning electron microscopeSE, Standard errorTEM, Transmission electron microscopyTriblock polymers PLGA-PEG-PEIZP, Zeta potential.

Identifiers

PMID36908304
PMCPMC9992749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.