Evidence map›Paper›PMID 36908218›Full record

ArticleRenal failure2023

Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients.

Dan Zhou, Huibin Yang, Li Zeng, Wei Yang, Fujia Guo, Wenting Cui, Cong Chen, Jiayao Zhao, Shuran Wu, Ning Yang and 3 more

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Article in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

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31citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. The effects of using a RovabioVeterinary research forum : an international quarterly journal · 2025
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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Dan ZhouDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Huibin YangFirst Affiliated Hospital, Dalian Medical University, Dalian, China.
Li ZengFirst Affiliated Hospital, Dalian Medical University, Dalian, China.
Wei YangDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Fujia GuoFirst Affiliated Hospital, Dalian Medical University, Dalian, China.
Wenting CuiDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Cong ChenFirst Affiliated Hospital, Dalian Medical University, Dalian, China.
Jiayao ZhaoFirst Affiliated Hospital, Dalian Medical University, Dalian, China.
Shuran WuDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Ning YangDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Hongli LinDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Anchun YinCollege of Integrative Medicine, Dalian Medical University, Dalian, China.
Longkai LiDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0000-0003-0607-4978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsComplete blood count (CBC)-derived inflammatory markers are predictive biomarkers for the prognosis of many diseases. However, there was no study on patients with peritoneal dialysis-associated peritonitis (PDAP). We aimed to investigate the value of these markers in predicting treatment failure of acute peritonitis in chronic PD patients.

methodsThe records of 138 peritonitis episodes were reviewed and divided into treatment success or failure groups in a single center for 10 years. CBC-derived markers and other routine data were recorded before peritonitis treatment was initiated. Univariate and multivariate regression analyses and the receiver operating characteristic (ROC) curve about the predictors of treatment outcomes were performed.

resultsNeutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and derived NLR were significantly higher in the failure group. Univariate logistic regression results showed that NLR and PLR were risk factors of treatment outcomes. The backward stepwise multivariate logistic regression results demonstrated that NLR [adjusted odds ratio (aOR), 1.376; 95% confidence intervals (CI), 1.105-1.713;

conclusionsNLR, PLR, HLR, and SII were associated with PDAP outcomes. Age, PD vintage, NLR, and PLR were significant risk factors in PDAP patients.

Indexed as

Peritoneal DialysisPeritonitisBlood Cell CountBlood PlateletsHumansInflammationLymphocytesNeutrophilsPrognosisRetrospective StudiesTreatment Failurehemoglobin-to-lymphocyte ratio (HLR)neutrophil-to-lymphocyte ratio (NLR)Peritoneal dialysisperitonitisplatelet-to-lymphocyte ratio (PLR)

Identifiers

PMID36908218
PMCPMC10013372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.