Evidence map›Paper›PMID 36907920›Full record

ArticleAnalytical and bioanalytical chemistry2023

Native diffusion of fluorogenic turn-on dyes accurately report interfacial chemical reaction locations.

Hannah Messenger, Daniel Madrid, Anuj Saini, Lydia Kisley

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hannah MessengerDepartment of Physics, Case Western Reserve University, 2076 Adelbert Road, Cleveland, OH, 44106, USA.
Daniel MadridDepartment of Physics, Case Western Reserve University, 2076 Adelbert Road, Cleveland, OH, 44106, USA.
Anuj SainiDepartment of Physics, Case Western Reserve University, 2076 Adelbert Road, Cleveland, OH, 44106, USA.
Lydia KisleyDepartment of Physics, Case Western Reserve University, 2076 Adelbert Road, Cleveland, OH, 44106, USA. lydia.kisley@case.edu.ORCID http://orcid.org/0000-0002-8286-5264
Case Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-molecule fluorescence microscopy with "turn-on" dyes that change fluorescent state after a reaction report on the chemistry of interfaces relevant to analytical and bioanalytical chemistry. Paramount to accurately understanding the phenomena at the ultimate detection limit of a single molecule is ensuring fluorophore properties such as diffusion do not obscure the chemical reaction of interest. Here, we develop Monte Carlo simulations of a dye that undergoes reduction to turn-on at the cathode of a corroded iron surface taking into account the diffusion of the dye molecules in a total internal reflection fluorescence (TIRF) excitation volume, location of the cathode, and chemical reactions. We find, somewhat counterintuitively, that a fast diffusion coefficient of D = 10

Indexed as

Fluorescent DyesComputer SimulationDiffusionMicroscopy, FluorescenceSpectrometry, FluorescenceFluorescent DyesFluorescenceInterfacial scienceMonte Carlo simulationSensingSingle-molecule microscopyStochastic modeling

Identifiers

PMID36907920
OpenAlexW4324017467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.