Evidence map›Paper›PMID 36907651›Full record

ArticleESC heart failure2023

Integrated care for older multimorbid heart failure patients: protocol for the ESCAPE randomized trial and cohort study.

Christine Zelenak, Jonas Nagel, Kristina Bersch, Lisa Derendorf, Frank Doyle, Tim Friede, Birgit Herbeck Belnap, Sebastian Kohlmann, Søren T Skou, Carlos A Velasco and 24 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 18 institutions in 9 countries.

Christine ZelenakDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Centre, Göttingen, Germany.
Jonas NagelDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Centre, Göttingen, Germany.
Kristina BerschClinical Trial Unit of the University Medical Center Göttingen, Göttingen, Germany.
Lisa DerendorfFaculty of Medicine and University Hospital of Cologne, Institute of Health Economics and Clinical Epidemiology, University of Cologne, Cologne, Germany.
Frank DoyleRoyal College of Surgeons in Ireland, Dublin, Ireland.
Tim FriedeDepartment of Medical Statistics, University of Göttingen Medical Centre, Göttingen, Germany.
Birgit Herbeck BelnapDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Centre, Göttingen, Germany.
Sebastian KohlmannClinic for Psychosomatic Medicine and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany.
Søren T SkouThe Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals, Region Zealand, Slagelse, Denmark.
Carlos A VelascoFraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany.
Christian AlbusFaculty of Medicine and University Hospital of Cologne, Department of Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany.
Thomas AsendorfClinical Trial Unit of the University Medical Center Göttingen, Göttingen, Germany.
Christian Axel BangDepartment of Cardiology, Zealand University Hospital, Roskilde, Denmark.
Margarita BeresnevaiteLaboratory of Clinical Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Niels Eske BruunDepartment of Cardiology, Zealand University Hospital, Roskilde, Denmark.
Matthew M BurgYale University School of Medicine, New Haven, CT, USA.
Sussi Friis BuhlResearch Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Peter H GaedeDepartment of Cardiology and Endocrinology, Slagelse Hospital, Slagelse, Denmark.
Dagmar LühmannUniversity Hospital Hamburg Eppendorf, Hamburg, Germany.
Anna MarkserFaculty of Medicine and University Hospital of Cologne, Department of Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany.
Klaudia Vivien NagyHeart and Vascular Center, Semmelweis University Budapest, Budapest, Hungary.
Chiara RafanelliDepartment of Psychology, University of Bologna, Bologna, Italy.
Sanne RasmussenResearch Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Jens SøndergaardResearch Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Jan SørensenHealthcare Outcomes Research Centre, Dublin, Ireland.
Adrienne StauderInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.
Stephanie StockFaculty of Medicine and University Hospital of Cologne, Institute of Health Economics and Clinical Epidemiology, University of Cologne, Cologne, Germany.
Stefano UrbinatiBellaria Hospital and University of Bologna, Bologna, Italy.
Diego Della RivaBellaria Hospital and University of Bologna, Bologna, Italy.
Rolf WachterUniversity Hospital of Leipzig, Leipzig, Germany.
Florian WalkerClinical Trial Unit of the University Medical Center Göttingen, Göttingen, Germany.
Susanne S PedersenDepartment of Psychology, University of Southern Denmark, Odense, Denmark.
Christoph Herrmann-LingenDepartment of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Centre, Göttingen, Germany.
ESCAPE consortium
University of Göttingen · DEUniversity of Cologne · DEUniversity of Southern Denmark · DKSemmelweis University · HUUniversität Hamburg · DEZealand University Hospital · DKFraunhofer Institute for Applied Information Technology · DEGNA University · INLithuanian University of Health Sciences · LTOspedale Bellaria · ITOutcomes Based Healthcare · GBRingsted Sygehus · DKRoyal College of Surgeons in Ireland · IESlagelse Hospital · DKUniversitätsmedizin Göttingen · DEUniversity Hospital Leipzig · DEUniversity of Bologna · ITYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

escapeEvaluation of a patient-centred biopsychosocial blended collaborative care pathway for the treatment of multimorbid elderly patients. THERAPEUTIC AREA: Healthcare interventions for the management of older patients with multiple morbidities.

aimsMulti-morbidity treatment is an increasing challenge for healthcare systems in ageing societies. This comprehensive cohort study with embedded randomized controlled trial tests an integrated biopsychosocial care model for multimorbid elderly patients. HYPOTHESIS: A holistic, patient-centred pro-active 9-month intervention based on the blended collaborative care (BCC) approach and enhanced by information and communication technologies can improve health-related quality of life (HRQoL) and disease outcomes as compared with usual care at 9 months.

methodsAcross six European countries, ESCAPE is recruiting patients with heart failure, mental distress/disorder plus ≥2 medical co-morbidities into an observational cohort study. Within the cohort study, 300 patients will be included in a randomized controlled assessor-blinded two-arm parallel group interventional clinical trial (RCT). In the intervention, trained care managers (CMs) regularly support patients and informal carers in managing their multiple health problems. Supervised by a clinical specialist team, CMs remotely support patients in implementing the treatment plan-customized to the patients' individual needs and preferences-into their daily lives and liaise with patients' healthcare providers. An eHealth platform with an integrated patient registry guides the intervention and helps to empower patients and informal carers. HRQoL measured with the EQ-5D-5L as primary endpoint, and secondary outcomes, that is, medical and patient-reported outcomes, healthcare costs, cost-effectiveness, and informal carer burden, will be assessed at 9 and ≥18 months.

conclusionsIf proven effective, the ESCAPE BCC intervention can be implemented in routine care for older patients with multiple morbidities across the participating countries and beyond.

Indexed as

Delivery of Health Care, IntegratedHeart FailureAgedCohort StudiesHumansMultimorbidityObservational Studies as TopicQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeBlended collaborative careDepressionHeart failureMulti-morbidityMultinational trialPsychological distressQuality of life

Identifiers

PMID36907651
PMCPMC10192276
OpenAlexW4323981521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.