Evidence map›Paper›PMID 36907022›Full record

ArticleJournal of pharmaceutical and biomedical analysis2023

LC-MS/MS quantitation of non-psychotropic cannabinoid cannabidiol in aqueous humor.

Alyssa S Aebersold, Akhilesh Kumar, Zhao-Hui Song

Open access · greenAbstract read
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alyssa S AebersoldDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, United States; Pearl Medical, Louisville, KY 40218, United States.
Akhilesh KumarDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, United States; Phyto LabTech, Salt Lake City, UT 84414, United States.
Zhao-Hui SongDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, United States. Electronic address: zhsong@louisville.edu.
University of Louisville · US

Funding

The effect of cannabidiol and the role of GPR3 in experimental autoimmune uveitisR21EY030186 · NEI · UNIVERSITY OF LOUISVILLE · PI SHAO, HUI, SONG, ZHAO-HUI · 2019 to 2020
$424k
NEI NIH HHS R21 EY030186
6 · The paper itself

Abstract

Cannabidiol (CBD) is the most abundant non-psychotropic phytocannabinoid isolated from Cannabis sativa. To support preclinical studies of ocular pharmacology of CBD, a bioanalytical method was developed and validated for quantification of CBD in aqueous humor using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Aqueous humor samples were subjected to protein precipitation by acetonitrile, followed by chromatographic separation using reversed phase LC on a Raptor ARC-18 column with mobile phase A: 0.1 % (v/v) formic acid in water (B) 0.1 % formic acid in acetonitrile (B) as eluents. Detection was carried out with a triple quadrupole mass spectrometer with electrospray ionization operated in positive ion mode. Stable-isotope labeled CBD (CBD-d

Indexed as

CannabidiolCannabinoidsAnimalsAqueous HumorChromatography, High Pressure LiquidChromatography, LiquidFormatesMiceReproducibility of ResultsTandem Mass SpectrometryCannabidiolCannabinoidsFormatesformic acidAqueous humorCannabidiolLiquid chromatographyTandem mass spectrometry

Identifiers

PMID36907022
PMCPMC10163896
OpenAlexW4323276556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.