Evidence map›Paper›PMID 36906677›Full record

ArticleCommunications medicine2023

Persistent COVID-19 symptoms in community-living older adults from the Canadian Longitudinal Study on Aging (CLSA).

Lauren E Griffith, Marla Beauchamp, Jacqueline McMillan, Sayem Borhan, Urun Erbas Oz, Christina Wolfson, Susan Kirkland, Nicole E Basta, Mary Thompson, Parminder Raina and 1 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 15 institutions in 1 country.

Lauren E GriffithDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Marla BeauchampLabarge Centre for Mobility in Aging, McMaster University, Hamilton, ON, Canada.
Jacqueline McMillanDivision of Geriatric Medicine, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-7090-9485
Sayem BorhanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Urun Erbas OzDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Christina WolfsonDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
Susan KirklandDepartment of Community Health & Epidemiology, Dalhousie University, Halifax, NS, Canada.
Nicole E BastaDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
Mary ThompsonDepartment of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada.
Parminder RainaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. praina@mcmaster.ca.ORCID http://orcid.org/0000-0002-8107-3193
Canadian Longitudinal Study on Aging (CLSA) Team
Impact · CADalhousie University · CAMemorial University of Newfoundland · CASimon Fraser University · CAUniversité de Sherbrooke · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Ottawa · CAMcGill University · CAMcGill University Health Centre · CAMcMaster University · CAMcMaster University Medical Centre · CAUniversity of Manitoba · CAUniversity of Victoria · CAUniversity of Waterloo · CA

Funding

Public Health Agency of Canada (Agence de la Santé Publique du Canada) NA
6 · The paper itself

Abstract

backgroundSymptom persistence in non-hospitalized COVID-19 patients, also known as Long COVID or Post-acute Sequelae of COVID-19, is not well characterized or understood, and few studies have included non-COVID-19 control groups.

methodsWe used data from a cross-sectional COVID-19 questionnaire (September-December 2020) linked to baseline (2011-2015) and follow-up (2015-2018) data from a population-based cohort including 23,757 adults 50+ years to examine how age, sex, and pre-pandemic physical, psychological, social, and functional health were related to the severity and persistence of 23 COVID-19-related symptoms experienced between March 2020 and questionnaire completion.

resultsThe most common symptoms are fatigue, dry cough, muscle/joint pain, sore throat, headache, and runny nose; reported by over 25% of participant who had (n = 121) or did not have (n = 23,636) COVID-19 during the study period. The cumulative incidence of moderate/severe symptoms in people with COVID-19 is more than double that reported by people without COVID-19, with the absolute difference ranging from 16.8% (runny nose) to 37.8% (fatigue). Approximately 60% of male and 73% of female participants with COVID-19 report at least one symptom persisting >1 month. Persistence >1 month is higher in females (aIRR = 1.68; 95% CI: 1.03, 2.73) and those with multimorbidity (aIRR = 1.90; 95% CI: 1.02, 3.49); persistence >3 months decreases by 15% with each unit increase in subjective social status after adjusting for age, sex and multimorbidity.

conclusionsMany people living in the community who were not hospitalized for COVID-19 still experience symptoms 1- and 3-months post infection. These data suggest that additional supports, for example access to rehabilitative care, are needed to help some individuals fully recover.

Identifiers

PMID36906677
PMCPMC10006564
OpenAlexW4323971895

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read83
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.