Evidence map›Paper›PMID 36906620›Full record

ArticleTranslational psychiatry2023

Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice.

Hanna E Stevens, Soraya Scuderi, Sarah C Collica, Simone Tomasi, Tamas L Horvath, Flora M Vaccarino

Open access · goldFull text read
In one paragraph

Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hanna E StevensChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA. hanna-stevens@uiowa.edu.ORCID 0000-0002-3906-0786
Soraya ScuderiChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA.
Sarah C CollicaChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA.
Simone TomasiChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA.
Tamas L HorvathDepartment of Neuroscience, Yale University, New Haven, CT, 06520, USA.ORCID 0000-0002-7522-4602
Flora M VaccarinoChild Study Center, Yale School of Medicine, New Haven, CT, 06520, USA.ORCID 0000-0003-2167-981X
Yale University · USUniversity of Iowa · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI Lane Strathearn · 2021 to 2026
$8.5M
Morphogenesis and Function of the Cerebral CortexR01MH067715 · NIMH · YALE UNIVERSITY · PI VACCARINO, FLORA M · 2004 to 2013
$3.8M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS P50 HD103556NIEHS NIH HHS P30 ES005605NIMH NIH HHS R01 MH067715
6 · The paper itself

Abstract

Fibroblast growth factor receptor 2 (FGFR2) is almost exclusively expressed in glial cells in postnatal mouse brain, but its impact in glia for brain behavioral functioning is poorly understood. We compared behavioral effects from FGFR2 loss in both neurons and astroglial cells and from FGFR2 loss in astroglial cells by using either the pluripotent progenitor-driven hGFAP-cre or the tamoxifen-inducible astrocyte-driven GFAP-creER

Indexed as

AstrocytesMemory, Short-TermReceptor, Fibroblast Growth Factor, Type 2AnimalsLocomotionMiceNeurogliaNeuronsFgfr2 protein, mouseReceptor, Fibroblast Growth Factor, Type 2

Identifiers

PMID36906620
PMCPMC10008554
OpenAlexW4323924031

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read43
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.