Evidence map›Paper›PMID 36906562›Full record

SynthesisBMC gastroenterology2023

Systematic review of cholangiocarcinoma in Africa: epidemiology, management, and clinical outcomes.

Akwi W Asombang, Nathaniel Chishinga, Mouhand F Mohamed, Alick Nkhoma, Jackson Chipaila, Bright Nsokolo, Martha Manda-Mapalo, Joao Filipe G Montiero, Lewis Banda, Kulwinder S Dua

Open access · goldFull text readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Hepato-pancreato-biliary surgery in West Africa: a timely capacity assessment.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Akwi W AsombangDivision of Gastroenterology/Hepatology, Massachusetts General Hospital, 15 Parkman Street, Wang 5, Boston, MA, 02114, USA. aasombang@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-8658-6772
Nathaniel ChishingaDepartment of Internal Medicine, Piedmont Athens Regional Hospital, 1270 Prince Avenue, Suite 102, Athens, GA, 30606, USA.
Mouhand F MohamedDepartment of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Alick NkhomaDepartment of Gastroenterology, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Staffordshire, ST4 6QG, UK.
Jackson ChipailaDepartment of Surgery, University Teaching Hospital-Adult Hospital, Lusaka, 10101, Zambia.
Bright NsokoloDepartment of Internal Medicine, Levy Mwanawasa Medical University, Levy Mwanawasa University Teaching Hospital, Lusaka, 10101, Zambia.
Martha Manda-MapaloDivision of Hematology/Oncology, Department of Internal Medicine, The University of New Mexico, Albuquerque, NM, 87106, USA.
Joao Filipe G MontieroDepartment of Medicine, Brown University, Providence, RI, 02903, USA.
Lewis BandaHematology/Oncology, Cancer Disease Hospital, Lusaka, 10101, Zambia.
Kulwinder S DuaDepartment of Medicine and Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Brown University · USUniversity Teaching Hospital · ZMCentre for Infectious Disease Research in Zambia · ZMMassachusetts General Hospital · USMedical College of Wisconsin · USPiedmont Athens Regional · USUniversity Hospitals of North Midlands NHS Trust · GBUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence, management, and clinical outcomes of cholangiocarcinoma in Africa are unknown. The aim is to conduct a comprehensive systematic review on the epidemiology, management, and outcomes of cholangiocarcinoma in Africa.

methodsWe searched PubMed, EMBASE, Web of Science and CINHAL from inception up to November 2019 for studies on cholangiocarcinoma in Africa. The results reported follow PRISMA guidelines. Quality of studies and risk of bias were adapted from a standard quality assessment tool. Descriptive data were expressed as numbers with proportions and Chi-squared test was used to compare proportions. P values < 0.05 were considered significant.

resultsA total of 201 citations were identified from the four databases. After excluding duplicates, 133 full texts were reviewed for eligibility, and 11 studies were included. The 11 studies are reported from 4 countries only: 8 are from North Africa (Egypt 6 and Tunisia 2), and 3 in Sub-Saharan Africa (2 in South Africa, 1 in Nigeria). Ten studies reported management and outcomes, while one study reported epidemiology and risk factors. Median age for cholangiocarcinoma ranged between 52 and 61 years. Despite the proportion with cholangiocarcinoma being higher among males than females in Egypt, this gender disparity could not be demonstrated in other African countries. Chemotherapy is mainly used for palliative care. Surgical interventions are curative and prevent cancer progression. Statistical analyses were performed with Stata 15.1.

conclusionThe known global major risk factors such as primary sclerosing cholangitis, Clonorchis sinensis and Opisthorchis viverrini infestation are rare. Chemotherapy treatment was mainly used for palliative treatment and was reported in three studies. Surgical intervention was described in at least 6 studies as a curative modality of treatment. Diagnostic capabilities such as radiographic imaging and endoscopic are lacking across the continent which most likely plays a role in accurate diagnosis.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaBile Ducts, IntrahepaticFemaleHumansMaleMiddle AgedRisk FactorsSouth AfricaAfricaCholangiocarcinomaEpidemiologyRisk factorsSystematic review

Identifiers

PMID36906562
PMCPMC10007746
OpenAlexW4323971731

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read43
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.