Evidence map›Paper›PMID 36906486›Full record

Observational studyJournal of pediatric surgery2023

Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival: An Observational Study.

Andrew M Fleming, Andrew J Murphy, Suraj Sarvode Mothi, Rodrigo B Interiano, Amos Loh, Mary E McCarville, Zachary Abramson, Sara A Mansfield, Hafeez Abdelhafeez, Andrew M Davidoff and 4 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Hepatoblastoma.Nature reviews. Disease primers · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Andrew M FlemingSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA. Electronic address: aflemin8@uthsc.edu.
Andrew J MurphySt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA; Le Bonheur Children's Hospital, Department of Surgery, Memphis, TN, USA. Electronic address: andrew.murphy@stjude.org.
Suraj Sarvode MothiSt. Jude Children's Research Hospital, Department of Biostatistics, Memphis, TN, USA.
Rodrigo B InterianoSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA; Le Bonheur Children's Hospital, Department of Surgery, Memphis, TN, USA.
Amos LohSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA.
Mary E McCarvilleSt. Jude Children's Research Hospital, Department of Diagnostic Imaging, Memphis, TN, USA.
Zachary AbramsonSt. Jude Children's Research Hospital, Department of Diagnostic Imaging, Memphis, TN, USA.
Sara A MansfieldSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA; Le Bonheur Children's Hospital, Department of Surgery, Memphis, TN, USA.
Hafeez AbdelhafeezSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA.
Andrew M DavidoffSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA.
Ankush GosainSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA; Le Bonheur Children's Hospital, Department of Surgery, Memphis, TN, USA.
Jessica A GartrellSt. Jude Children's Research Hospital, Department of Oncology, Memphis, TN, USA.
Wayne L FurmanSt. Jude Children's Research Hospital, Department of Oncology, Memphis, TN, USA.
Max R LanghamSt. Jude Children's Research Hospital, Department of Surgery, Memphis, TN, USA; The University of Tennessee Health Science Center, Department of Surgery, Memphis, TN, USA; Le Bonheur Children's Hospital, Department of Surgery, Memphis, TN, USA.
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

backgroundThe utility of repeated surgical interventions in hepatoblastoma to achieve no evidence of disease (NED) is not well-defined. We examined the effect of aggressive pursuit of NED status on event-free (EFS) and overall survival (OS) in hepatoblastoma with subgroup analysis of high-risk patients.

methodsHospital records were queried for patients with hepatoblastoma from 2005 to 2021. Primary outcomes were OS and EFS stratified by risk and NED status. Group comparisons were performed using univariate analysis and simple logistic regression. Survival differences were compared with log-rank tests.

resultsFifty consecutive patients with hepatoblastoma were treated. Forty-one (82%) were rendered NED. NED was inversely correlated with 5-year mortality (OR 0.006; CI 0.001-0.056; P < .01). Ten-year OS (P < .01) and EFS (P < .01) were improved by achieving NED. Ten-year OS was similar between 24 high-risk and 26 not high-risk patients when NED was attained (P = .83). Fourteen high-risk patients underwent a median of 2.5 pulmonary metastasectomies, 7 for unilateral disease, and 7 for bilateral, with a median of 4.5 nodules resected. Five high-risk patients relapsed, and three were salvaged.

conclusionsNED status is necessary for survival in hepatoblastoma. Repeated pulmonary metastasectomy and/or complex local control strategies to obtain NED can achieve long-term survival in high-risk patients. LEVEL OF EVIDENCE: Level III - Treatment Study - Retrospective Comparative Study.

Indexed as

HepatoblastomaLiver NeoplasmsMetastasectomyDisease-Free SurvivalHumansRetrospective StudiesCancerHepatoblastomaLiverPediatricPulmonary metastases

Identifiers

PMID36906486
PMCPMC10198831
OpenAlexW4321189558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.