SynthesisJournal of pediatric urology2023
Primary ablation versus urinary diversion in posterior urethral valve: Systematic review and meta-analysis.
Synthesis in Journal of pediatric urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Long-term renal outcomes in children with posterior urethral valves: a systematic review and meta-analysis.Pediatric surgery international · 2026Pooled it
- Fetal bladder rupture in posterior urethral valves: a clinically relevant complication or a protective pop-off mechanism.Frontiers in pediatrics · 2026Pooled it
- Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function.Pediatric nephrology (Berlin, Germany) · 2026Article
- Post-transplant kidney function decline in children with posterior urethral valves versus non-urologic etiologies: roles of catheterization, infection, and rejection.Pediatric nephrology (Berlin, Germany) · 2026Article
- Early diagnosis and intervention in congenital lower urinary tract obstruction: time to revise our approach?Pediatric nephrology (Berlin, Germany) · 2026Review
- Impact of a standardized care pathway and a dedicated multidisciplinary posterior urethral valve clinic on 5-year kidney and bladder outcomes.Pediatric nephrology (Berlin, Germany) · 2025Article
- Lower Urinary Tract Symptoms in Patients with Congenital Genitourinary Anomalies.Current urology reports · 2025Review
- Development and international validation of a novel multivariate prognostic tool: posterior urethral valve risk of chronic kidney disease (PURK) score.Pediatric nephrology (Berlin, Germany) · 2025Article
- Care of children with posterior urethral valves after initial endoscopic incision/ablation: what a nephrologist needs to know.Pediatric nephrology (Berlin, Germany) · 2025Review
- Risk Factors for Early Chronic Kidney Disease IV-V in Children with Posterior Urethral Valves: A Retrospective Cohort Study.Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo determine differences in long-term kidney and bladder outcomes in boys with posterior urethral valves (PUV) managed by a primary valve ablation or primary urinary diversion. MATERIALS AND
methodsA systematic search was performed in March 2021. Comparative studies were evaluated according to Cochrane collaboration recommendations. Assessed measures included kidney outcomes (chronic kidney disease, end-stage renal disease, kidney function) and bladder outcomes. Odds ratios (OR) and mean difference (MD) with 95% confidence interval (CI) were extrapolated from available data for quantitative synthesis. Random-effects meta-analysis and meta-regression were performed according to study design, and potential covariates were assessed with subgroup analysis. The systematic review was prospectively registered on PROSPERO (CRD42021243967).
resultsThirty unique studies describing 1547 boys with PUV were included in this synthesis. Overall effect estimates demonstrate that patients undergoing primary diversion have significantly increased odds of developing renal insufficiency [OR 0.60, 95% CI 0.44, 0.80; p < 0.001]. However, when adjusting for baseline kidney function between intervention groups, there was no significant difference in long term kidney outcomes [p = 0.09, 0.35], or the development of bladder dysfunction or requiring clean-intermittent catheterization with primary ablation rather than diversion [OR 0.89, 95% CI 0.49, 1.59; p = 0.68].
conclusionsCurrent low-quality evidence suggests that medium-term kidney outcomes in children are similar between primary ablation and primary diversion after adjusting for baseline kidney function, while bladder outcomes are highly heterogenous. Further research with covariate control is warranted to investigate sources of heterogeneity. LEVEL OF EVIDENCE: Level III.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.