Evidence map›Paper›PMID 36906445›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Free-Water Diffusion Magnetic Resonance Imaging Differentiates Suicidal Ideation From Suicide Attempt in Treatment-Resistant Depression.

Katie L Vandeloo, Patricia Burhunduli, Sylvain Bouix, Kimia Owsia, Kang Ik K Cho, Zhuo Fang, Amanda Van Geel, Ofer Pasternak, Pierre Blier, Jennifer L Phillips

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Katie L VandelooUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Patricia BurhunduliUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Sylvain BouixDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Kimia OwsiaUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada.
Kang Ik K ChoDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Zhuo FangUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada.
Amanda Van GeelUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Pierre BlierUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada.
Jennifer L PhillipsUniversity of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada; Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: Jennifer.Phillips@theroyal.ca.
University of Ottawa · CABrigham and Women's Hospital · USCarleton University · CA

Funding

High Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1M
NIMH NIH HHS R01 MH112748
6 · The paper itself

Abstract

backgroundSuicide attempt is highly prevalent in treatment-resistant depression (TRD); however, the neurobiological profile of suicidal ideation versus suicide attempt is unclear. Neuroimaging methods including diffusion magnetic resonance imaging-based free-water imaging may identify neural correlates underlying suicidal ideation and attempts in individuals with TRD.

methodsDiffusion magnetic resonance imaging data were obtained from 64 male and female participants (mean age 44.5 ± 14.2 years), including 39 patients with TRD (n = 21 and lifetime history of suicidal ideation but no attempts [SI group]; n = 18 with lifetime history of suicide attempt [SA group]), and 25 age- and sex-matched healthy control participants. Depression and suicidal ideation severity were examined using clinician-rated and self-report measures. Whole-brain neuroimaging analysis was conducted using tract-based spatial statistics via FSL to identify differences in white matter microstructure in the SI versus SA groups and in patients versus control participants.

resultsFree-water imaging revealed elevated axial diffusivity and extracellular free water in fronto-thalamo-limbic white matter tracts of the SA group compared with the SI group. In a separate comparison, patients with TRD had widespread reductions in fractional anisotropy and axial diffusivity, as well as elevated radial diffusivity compared with control participants (thresholded p < .05, familywise error corrected).

conclusionsA unique neural signature consisting of elevated axial diffusivity and free water was identified in patients with TRD and suicide attempt history. Findings of reduced fractional anisotropy, axial diffusivity, and elevated radial diffusivity in patients versus control participants are consistent with previously published studies. Multimodal and prospective investigations are recommended to better understand biological correlates of suicide attempt in TRD.

Indexed as

Suicidal IdeationSuicide, AttemptedAdultDepressionDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedProspective StudiesWaterWaterDiffusion tensor imagingFree-water imagingSuicidal ideationSuicide attemptTreatment-resistant depressionWhite matter

Identifiers

PMID36906445
PMCPMC11421579
OpenAlexW4312084865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.