Evidence map›Paper›PMID 36905875›Full record

ArticleGynecologic oncology2023

Fear of recurrence, emotional well-being and quality of life among long-term advanced ovarian cancer survivors.

Kathryn Osann, Lari Wenzel, Chelsea McKinney, Lynne Wagner, David Cella, Giulia Fulci, Mary J Scroggins, Heather A Lankes, Victoria Wang, Kenneth P Nephew and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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  9. Symptom burden, palliative care knowledge, and palliative care needs in advanced gynecological cancer patients in Korea.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Kathryn OsannDepartment of Medicine and Program in Public Health, University of California, 839 Health Sciences Rd, Irvine, CA 92697, USA. Electronic address: kosann@uci.edu.
Lari WenzelDepartment of Medicine and Program in Public Health, University of California, 839 Health Sciences Rd, Irvine, CA 92697, USA. Electronic address: lwenzel@uci.edu.
Chelsea McKinneyDepartment of Medicine and Program in Public Health, University of California, 839 Health Sciences Rd, Irvine, CA 92697, USA. Electronic address: comckinn@uci.edu.
Lynne WagnerDepartment of Social Sciences and Health Policy, Wake Forest University, 475 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: lywagner@wakehealth.edu.
David CellaDepartment of Medical Social Sciences, Northwestern University Health System, 633 N St Clair St, Chicago, IL 60611, USA. Electronic address: d-cella@northwestern.edu.
Giulia FulciGlaxoSmithKline, 1000 Winter St, Waltham, MA 02451, USA.
Mary J ScrogginsInternational Gynecology Cancer Society, PO Box 170645, Austin, TX 78717, USA.
Heather A LankesThe GOG Foundation, Inc., Edgewater, MD 21037, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: hlankes@gog.org.
Victoria WangDana-Farber Cancer Institute, Department of Data Science, 450 Brookline Ave LC1052 or LC9310, Boston, MA 02215, USA. Electronic address: vwang@jimmy.harvard.edu.
Kenneth P NephewMedical Sciences Program, Indiana University School of Medicine-Bloomington, 1001 E 3rd St, Bloomington, IN, 47405, USA. Electronic address: knephew@indiana.edu.
George L MaxwellWomen's Health Integrated Research Center at Inova Health System, Women's Service Line, Inova Health System, 8110 Gatehouse Rd, Falls Church, VA 22042, USA. Electronic address: george.maxwell@inova.org.
Samuel C MokDepartment of Gynecological Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77230, USA. Electronic address: scmok@mdanderson.org.
Thomas P ConradsWomen's Health Integrated Research Center at Inova Health System, Women's Service Line, Inova Health System, 8110 Gatehouse Rd, Falls Church, VA 22042, USA. Electronic address: conrads@whirc.org.
Austin MillerRoswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY 14203, USA. Electronic address: millera@nrgoncology.org.
Michael BirrerWinthrop P. Rockefeller Cancer Institute University of Arkansas for Medical Sciences, 4301 W. Markham St, Little Rock, AR 72205, USA. Electronic address: mjbirrer@uams.edu.
University of California, Irvine · USInova Health System · USDana-Farber Cancer Institute · USGlaxoSmithKline (United States) · USGynecologic Oncology Group · USIndiana University School of MedicineNorthwestern University · USRoswell Park Comprehensive Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Arkansas for Medical Sciences · USWake Forest University · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

objectiveAlthough advanced stage epithelial ovarian cancer is widely considered life-threatening, 17% of women with advanced disease will survive long-term. Little is known about the health-related quality of life (QOL) of long-term ovarian cancer survivors, or how fear of recurrence might affect QOL.

methods58 long-term survivors with advanced disease participated in the study. Participants completed standardized questionnaires to capture cancer history, QOL, and fear of recurrent disease (FOR). Statistical analyses included multivariable linear models.

resultsParticipants averaged 52.8 years at diagnosis and had survived >8 years (mean:13.5); 64% had recurrent disease. Mean FACT-G, FACT-O, and FACT-O-TOI (TOI) scores were 90.7 (SD:11.6), 128.6 (SD:14.8), and 85.9 (SD:10.2) respectively. Compared to the U.S. population using T-scores, QOL for participants exceeded that of healthy adults (T-score (FACT-G) = 55.9). Overall QOL was lower in women with recurrent vs. non-recurrent disease though differences did not reach statistical significance (FACT-O = 126.1 vs. 133.3, p = 0.082). Despite good QOL, high FOR was reported in 27%. FOR was inversely associated with emotional well-being (EWB) (p < 0.001), but not associated with other QOL subdomains. In multivariable analysis, FOR was a significant predictor of EWB after adjusting for QOL (TOI). A significant interaction was observed between recurrence and FOR (p = 0.034), supporting a larger impact of FOR in recurrent disease.

conclusionQOL in long-term ovarian cancer survivors was better than the average for healthy U.S. women. Despite good QOL, high FOR contributed significantly to increased emotional distress, most notably for those with recurrence. Attention to FOR may be warranted in this survivor population.

Indexed as

Cancer SurvivorsOvarian NeoplasmsAdultCarcinoma, Ovarian EpithelialFearFemaleHumansQuality of LifeEmotional well-beingFear of recurrenceLong-term survivalOvarian cancerQuality of life

Identifiers

PMID36905875
PMCPMC10681156
OpenAlexW4323870786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.