Evidence map›Paper›PMID 36905832›Full record

ArticleColloids and surfaces. B, Biointerfaces2023

Comparative electrokinetic properties of extracellular vesicles produced by yeast and bacteria.

Nicholas M K Rogers, Alexander W McCumber, Hannah M McMillan, Ryan P McNamara, Dirk P Dittmer, Meta J Kuehn, Christine Ogilvie Hendren, Mark R Wiesner

Open access · greenAbstract read
In one paragraph

Article in Colloids and surfaces. B, Biointerfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Membrane Vesicles ImproveMicroorganisms · 2026
    Article
  3. Preparation ofBioengineering (Basel, Switzerland) · 2026
    Article
  4. Extracellular vesicles as indicators of environmental stress response inExtracellular vesicles and circulating nucleic acids · 2026
    Article
  5. Article
  6. Article
  7. Functional properties ofMicrobiology (Reading, England) · 2025
    Article
  8. Review
  9. Article
  10. Stress Conditions Affect the Immunomodulatory Potential ofInternational journal of molecular sciences · 2023
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nicholas M K RogersDepartment of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, Israel; Porter School of Earth and Environmental Studies, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: nmkrogers093@tauex.tau.ac.il.
Alexander W McCumberDepartment of Environmental Sciences and Engineering, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Hannah M McMillanDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Ryan P McNamaraDepartment of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Dirk P DittmerDepartment of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Meta J KuehnDepartment of Biochemistry, Duke University, Durham, NC, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Christine Ogilvie HendrenCenter for the Environmental Implications of Nanotechnology, Duke University, Durham, NC, USA; Department of Geological and Environmental Sciences, Appalachian State University, Boone, NC, USA; Research Institute for Environment, Energy and Economics, Appalachian State University, Boone, NC, USA.
Mark R WiesnerDepartment of Civil & Environmental Engineering, Duke University, Durham, NC, USA; Center for the Environmental Implications of Nanotechnology, Duke University, Durham, NC, USA.
Duke University · USUniversity of North Carolina at Chapel Hill · USAppalachian State University · USTel Aviv University · IL

Funding

ART Modulation of Viral Pathogenesis in Oral EpitheliaR01DE018304 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DITTMER, DIRK P · 2007 to 2025
$6.9M
Impact of HIV on the Tumor MicroenvironmentR01CA228172 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, DITTMER, DIRK P · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA228172NIDCR NIH HHS R01 DE018304
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are nano-sized, biocolloidal proteoliposomes that have been shown to be produced by all cell types studied to date and are ubiquitous in the environment. Extensive literature on colloidal particles has demonstrated the implications of surface chemistry on transport behavior. Hence, one may anticipate that physicochemical properties of EVs, particularly surface charge-associated properties, may influence EV transport and specificity of interactions with surfaces. Here we compare the surface chemistry of EVs as expressed by zeta potential (calculated from electrophoretic mobility measurements). The zeta potentials of EVs produced by Pseudomonas fluorescens, Staphylococcus aureus, and Saccharomyces cerevisiae were largely unaffected by changes in ionic strength and electrolyte type, but were affected by changes in pH. The addition of humic acid altered the calculated zeta potential of the EVs, especially for those from S. cerevisiae. Differences in zeta potential were compared between EVs and their respective parent cell with no consistent trend emerging; however, significant differences were discovered between the different cell types and their EVs. These findings imply that, while EV surface charge (as estimated from zeta potential) is relatively insensitive to the evaluated environmental conditions, EVs from different organisms can differ regarding which conditions will cause colloidal instability.

Indexed as

Extracellular VesiclesSaccharomyces cerevisiaeBacteriaBacteriaColloidal stabilityEnvironmental fateExtracellular vesicleSurface potentialYeastZeta potential

Identifiers

PMID36905832
PMCPMC10085849
OpenAlexW4323316761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.