Evidence map›Paper›PMID 36905565›Full record

ArticleInvestigational new drugs2023

Effective anticancer agents based-on two Pillar[5]arene derivatives for pancreas cancer cell lines: synthesis, apoptotic effect, caspase pathway.

Mehmet Ali Karaselek, Serkan Kuccukturk, Tugce Duran, Ahmed Nuri Kursunlu, Mustafa Ozmen, Ceren Bozdag, Selman Alkan, Alper Varman, Mehmet Aykut Yildirim, Tevfik Kucukkartallar and 1 more

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In one paragraph

Article in Investigational new drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Mehmet Ali KaraselekMeram Medicine Faculty, Department of Internal Medicine, Necmettin Erbakan University, Konya, 42080, Türkiye.
Serkan KuccukturkMedicine Faculty, Department of Medical Biology, Karamanoglu Mehmetbey University, Karaman, 70100, Türkiye.
Tugce DuranMedicine Faculty, Department of Medical Genetic, KTO Karatay University, Konya, 42020, Türkiye.
Ahmed Nuri KursunluScience Faculty, Department of Chemistry, Selcuk University, Konya, 42250, Türkiye. ankursunlu@hotmail.com.
Mustafa OzmenScience Faculty, Department of Chemistry, Selcuk University, Konya, 42250, Türkiye.
Ceren BozdagScience Faculty, Department of Chemistry, Selcuk University, Konya, 42250, Türkiye.
Selman AlkanMeram Medicine Faculty, Department of General Surgery, Necmettin Erbakan University, Konya, 42080, Türkiye.
Alper VarmanMeram Medicine Faculty, Department of General Surgery, Necmettin Erbakan University, Konya, 42080, Türkiye.
Mehmet Aykut YildirimMeram Medicine Faculty, Department of General Surgery, Necmettin Erbakan University, Konya, 42080, Türkiye.
Tevfik KucukkartallarMeram Medicine Faculty, Department of General Surgery, Necmettin Erbakan University, Konya, 42080, Türkiye.
Celalettin VatansevMeram Medicine Faculty, Department of General Surgery, Necmettin Erbakan University, Konya, 42080, Türkiye.
Necmettin Erbakan University · TRSelçuk University · TRKaramanoğlu Mehmetbey University · TRKTO Karatay University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the possible anticancer effects of two different pillar[5]arene derivatives (5Q-[P5] and 10Q-P[5]) on two different pancreatic cancer cell lines in vitro. For this purpose, changes in the expression of major genes that play a role in apoptosis and caspase pathways were investigated. Panc-1 and BxPC-3 cell lines were used in the study and the cytotoxic dose of pillar[5]arenes was determined by the MTT method. Changes in gene expression after pillar[5]arenes treatment were evaluated by real-time polymerase chain reaction (qPCR). Apoptosis was studied by flow cytometry. As a result of analysis, it was determined that proapoptotic genes and genes involved in major caspase activation were upregulated and antiapoptotic genes were down-regulated in Panc-1 cell line treated with pillar[5]arenes. Flow cytometric apoptosis analysis also showed an increased apoptosis rate in this cell line. On the contrary, although MTT analysis showed cytotoxic effect in BxPC-3 cell line treated with two pillar[5]arene derivatives, the apoptosis pathway was not active. This suggested that it may activate different death pathways for BxPC-3 cell line. Thus, it was first determined that the pillar[5]arene derivatives reduced cancer cell proliferation on pancreatic cancer cells.

Indexed as

Antineoplastic AgentsPancreatic NeoplasmsApoptosisCalixarenesCaspasesCell Line, TumorCell ProliferationHumansQuaternary Ammonium CompoundsAntineoplastic AgentsCalixarenesCaspasespillar(5)areneQuaternary Ammonium CompoundsBxPC-3Panc-1Pancreas cancerPillar[5]aren

Identifiers

PMID36905565
OpenAlexW4323921076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.