Evidence map›Paper›PMID 36905559›Full record

ArticleArchives of osteoporosis2023

Treatment rates and healthcare costs of patients with fragility fracture by site of care: a real-world data analysis.

A Singer, M R McClung, O Tran, C D Morrow, S Goldstein, R Kagan, M McDermott, A Yehoshua

Open access · hybridFull text read
In one paragraph

Article in Archives of osteoporosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Trends and disparities in DXA testing for osteoporosis among Medicare beneficiaries, 2005-2023.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  5. Article
  6. Association of frailty trajectories with osteoporosis and hip fracture in an older female population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Burden of accumulating fragility fractures on health service usage and costs among post-menopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Technology behind augmenting fracture healing.Bulletin of the Hospital for Joint Disease (2013) · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. No Significant Improvement in Osteoporosis Management of Post-fragility Fracture Patients From 2010 to 2019: A National Database Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

A SingerMedStar Georgetown University Hospital, Washington, DC, USA.
M R McClungOregon Osteoporosis Center, Portland, OR, USA.
O TranMerative, Cambridge, MA, USA.
C D MorrowMerative, Cambridge, MA, USA.
S GoldsteinNYU Grossman School of Medicine, New York, NY, USA.
R KaganUniversity of California, San Francisco, CA, USA.
M McDermottAmgen Inc, Thousand Oaks, CA, USA. mmcder02@amgen.com.
A YehoshuaAmgen Inc, Thousand Oaks, CA, USA.
Amgen (United States) · USBone Health and Osteoporosis Foundation · USGeorgetown University · USNew York University · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a characterization of treatment rates and healthcare costs among patients with an osteoporotic-related fragility fracture overall and by site of care, costs were high and treatment rates were low. PURPOSE: Osteoporotic fractures can be debilitating, even fatal, among older adults. The cost of osteoporosis and related fractures is projected to increase to more than $25 billion by 2025. The objective of this analysis is to characterize disease-related treatment rates and healthcare costs of patients with an osteoporotic fragility fracture overall and by site of fracture diagnosis.

methodsIn this retrospective analysis, individuals with fragility fractures were identified in the Merative MarketScan® Commercial and Medicare Databases among women 50 years of age or older and diagnosed with fragility fracture between 1/1/2013 and 6/30/2018 (earliest fracture diagnosis = index). Cohorts were categorized by clinical site of care where the diagnosis of fragility fracture was made and were continuously followed for 12 months prior to and following index. Sites of care were inpatient admission, outpatient office, outpatient hospital, emergency room hospital, and urgent care.

resultsOf the 108,965 eligible patients with fragility fracture (mean age 68.8), most were diagnosed during an inpatient admission or outpatient office visit (42.7%, 31.9%). The mean annual healthcare costs among patients with fragility fracture were $44,311 (± $67,427) and were highest for those diagnosed in an inpatient setting ($71,561 ± $84,072). Compared with other sites of care at fracture diagnosis, patients diagnosed during an inpatient admission also had highest proportion of subsequent fractures (33.2%), osteoporosis diagnosis (27.7%), and osteoporosis therapy (17.2%) during follow-up.

conclusionThe site of care for diagnosis of fragility fracture affects treatment rates and healthcare costs. Further studies are needed to determine how attitude or knowledge about osteoporosis treatment or healthcare experiences differ at various clinical sites of care in the medical management of osteoporosis.

Indexed as

Bone Density Conservation AgentsOsteoporosisOsteoporotic FracturesAgedData AnalysisFemaleHealth Care CostsHumansMedicareRetrospective StudiesUnited StatesBone Density Conservation AgentsAgedBone density conservation agentsBone density/drug effectsCost of illnessFemaleHealth care costsHospitalizationHumansMedicareMiddle agedPostmenopausalRisk assessmentUSA/epidemiology

Identifiers

PMID36905559
PMCPMC10008255
OpenAlexW4323921036

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read435
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.