Evidence map›Paper›PMID 36905557›Full record

ArticleBiological trace element research2023

Chrysin Encapsulated Copper Nanoparticles with Low Dose of Gamma Radiation Elicit Tumor Cell Death Through p38 MAPK/NF-κB Pathways.

Lubna O Abdelhakm, Eman I Kandil, Somaya Z Mansour, Sawsan M El-Sonbaty

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Article in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lubna O AbdelhakmBiochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Eman I KandilBiochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Somaya Z MansourRadiation Biology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
Sawsan M El-SonbatyRadiation Microbiology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt. sawsansonbaty@yahoo.com.ORCID http://orcid.org/0000-0002-2611-2065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improving radiation effect on tumor cells using radiosensitizers is gaining traction for improving chemoradiotherapy. This study aimed to evaluate copper nanoparticles (CuNPs) synthesized using chrysin as radiosensitizer with γ-radiation on biochemical and histopathological approaches in mice bearing Ehrlich solid tumor. CuNPs were characterized with irregular round sharp shape with size range of 21.19-70.79 nm and plasmon absorption at 273 nm. In vitro study on MCF-7 cells detected cytotoxic effect of CuNPs with IC

Indexed as

NanoparticlesNF-kappa BAnimalsApoptosisCopperFlavonoidsGamma RaysMicep38 Mitogen-Activated Protein KinaseschrysinCopperFlavonoidsNF-kappa Bp38 Mitogen-Activated Protein KinasesApoptosisCopper nanoparticlesCyclinD1Ehrlich solid tumorLow dose radiationNF-κBp38 MAPK

Identifiers

PMID36905557
PMCPMC10509080

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.