Evidence map›Paper›PMID 36904999›Full record

ArticleSensors (Basel, Switzerland)2023

Photoacoustic Imaging of COVID-19 Vaccine Site Inflammation of Autoimmune Disease Patients.

Janggun Jo, David Mills, Aaron Dentinger, David Chamberland, Nada M Abdulaziz, Xueding Wang, Elena Schiopu, Girish Gandikota

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Janggun JoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8131-7197
David MillsGeneral Electric Research, Niskayuna, NY 12309, USA.
Aaron DentingerGeneral Electric Research, Niskayuna, NY 12309, USA.
David ChamberlandDepartment of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA.
Nada M AbdulazizDepartment of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Elena SchiopuDivision of Rheumatology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Girish GandikotaDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
University of Michigan · USGeneral Electric (United States) · USAugusta University · US

Funding

Physiology of Inflammatory Arthritis in High ResolutionR01AR060350 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, XUEDING · 2011 to 2021
$6.0M
NIAMS NIH HHS R01 AR060350NIH HHS R01AR060350
6 · The paper itself

Abstract

Based on the observations made in rheumatology clinics, autoimmune disease (AD) patients on immunosuppressive (IS) medications have variable vaccine site inflammation responses, whose study may help predict the long-term efficacy of the vaccine in this at-risk population. However, the quantitative assessment of the inflammation of the vaccine site is technically challenging. In this study analyzing AD patients on IS medications and normal control subjects, we imaged the inflammation of the vaccine site 24 h after mRNA COVID-19 vaccinations were administered using both the emerging photoacoustic imaging (PAI) method and the established Doppler ultrasound (US) method. A total of 15 subjects were involved, including 6 AD patients on IS and 9 normal control subjects, and the results from the two groups were compared. Compared to the results obtained from the control subjects, the AD patients on IS medications showed statistically significant reductions in vaccine site inflammation, indicating that immunosuppressed AD patients also experience local inflammation after mRNA vaccination but not in as clinically apparent of a manner when compared to non-immunosuppressed non-AD individuals. Both PAI and Doppler US were able to detect mRNA COVID-19 vaccine-induced local inflammation. PAI, based on the optical absorption contrast, shows better sensitivity in assessing and quantifying the spatially distributed inflammation in soft tissues at the vaccine site.

Indexed as

Autoimmune DiseasesCOVID-19Photoacoustic TechniquesVaccinesCOVID-19 VaccinesHumansInflammationCOVID-19 VaccinesVaccinesautoimmune diseaseCOVID-19 vaccineDoppler ultrasound imagingimmunosuppressive medicinephotoacoustic imagingvaccine site inflammation

Identifiers

PMID36904999
PMCPMC10006996
OpenAlexW4323315281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.