Evidence map›Paper›PMID 36904975›Full record

ArticleSensors (Basel, Switzerland)2023

Numerical Study of Particle Separation through Integrated Multi-Stage Surface Acoustic Waves and Modulated Driving Signals.

Yingqi Jiang, Jin Chen, Weipeng Xuan, Yuhao Liang, Xiwei Huang, Zhen Cao, Lingling Sun, Shurong Dong, Jikui Luo

Full text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Recent advances in responsive isolation, release and clinical application of circulating tumor cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingqi JiangMinistry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.
Jin ChenMinistry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.
Weipeng XuanMinistry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.ORCID 0000-0002-4818-2881
Yuhao LiangMinistry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.
Xiwei HuangMinistry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.ORCID 0000-0002-2364-0479
Zhen CaoKey Laboratory of Advanced Micro/Nano Electronics Devices & Smart Systems of Zhejiang, College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China.ORCID 0000-0002-5440-3628
Lingling SunMinistry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.
Shurong DongKey Laboratory of Advanced Micro/Nano Electronics Devices & Smart Systems of Zhejiang, College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China.ORCID 0000-0002-8715-7072
Jikui LuoKey Laboratory of Advanced Micro/Nano Electronics Devices & Smart Systems of Zhejiang, College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China.ORCID 0000-0003-0310-2443

Funding

National Key R&D Program of China (No.2021YFB3602200)National Natural Science Foundation of China (No. 61827806, 61974037)NSFC-Zhejiang Joint Fund for the Integration of Industrialization and information (No. U20A20172)Zhejiang Province Key R & D programs (No. 2021C05004, 2023C01192)
6 · The paper itself

Abstract

The manipulation of biomedical particles, such as separating circulating tumor cells from blood, based on standing surface acoustic wave (SSAW) has been widely used due to its advantages of label-free approaches and good biocompatibility. However, most of the existing SSAW-based separation technologies are dedicated to isolate bioparticles in only two different sizes. It is still challenging to fractionate various particles in more than two different sizes with high efficiency and accuracy. In this work, to tackle the problems of low efficiency for multiple cell particle separation, integrated multi-stage SSAW devices with different wavelengths driven by modulated signals were designed and studied. A three-dimensional microfluidic device model was proposed and analyzed using the finite element method (FEM). In addition, the effect of the slanted angle, acoustic pressure, and the resonant frequency of the SAW device on the particle separation were systemically studied. From the theoretical results, the separation efficiency of three different size particles based on the multi-stage SSAW devices reached 99%, which was significantly improved compared with conventional single-stage SSAW devices.

Indexed as

multi-stage sortingparticle sortingstanding surface acoustic waves

Identifiers

PMID36904975
PMCPMC10006892

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.