ArticlePolymers2023
Preparation and Characterization of Nanocomposite Hydrogels Based on Self-Assembling Collagen and Cellulose Nanocrystals.
Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential.Gels (Basel, Switzerland) · 2025Review
- A collagen-based bilayer nanocomposite scaffold for osteochondral tissue regeneration: integrating hydroxyapatite and cellulose nanocrystals.Journal of materials science. Materials in medicine · 2025Article
- Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.Biomaterials · 2025Article
- Obtaining and Characterizing Poly(Acid Acrylic-co-Acrylamide) Hydrogels Reinforced with Cellulose Nanocrystals fromGels (Basel, Switzerland) · 2025Article
- Preparation and Properties of Sodium Carboxymethyl Cellulose Microspheres by Dropping Method.ACS omega · 2025Article
- [Preparation of collagen-polysaccharide composite hydrogels and research progress in biomedical applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.bioRxiv : the preprint server for biology · 2024Article
- Amine-reactive crosslinking enhances type 0 collagen hydrogel properties for regenerative medicine.Frontiers in bioengineering and biotechnology · 2024Article
- Nanocrystalline Cellulose as a Versatile Engineering Material for Extrusion-Based Bioprinting.Pharmaceutics · 2023Article
- Cellular infiltration in an injectable sulfated cellulose nanocrystal hydrogel and efficient angiogenesis by VEGF loading.Biomaterials research · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
Collagen (Col) hydrogels are an important biomaterial with many applications in the biomedical sector. However, deficiencies, including insufficient mechanical properties and a rapid rate of biodegradation, hamper their application. In this work, nanocomposite hydrogels were prepared by combining a cellulose nanocrystal (CNC) with Col without any chemical modification. The high-pressure, homogenized CNC matrix acts as nuclei in the collagen's self-aggregation process. The obtained CNC/Col hydrogels were characterized in terms of their morphology, mechanical and thermal properties and structure by SEM, rotational rheometer, DSC and FTIR, respectively. Ultraviolet-visible spectroscopy was used to characterize the self-assembling phase behavior of the CNC/Col hydrogels. The results showed an accelerated assembling rate with the increasing loading of CNC. The triple-helix structure of the collagen was preserved with a dosage of CNC of up to 15 wt%. The CNC/Col hydrogels demonstrated an improvement in both the storage modulus and thermal stability which is attributed to the interaction between the CNC and collagen by the hydrogen bonds.
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