ArticlePolymers2023
Development of Crosslinker-Free Polysaccharide-Lysozyme Microspheres for Treatment Enteric Infection.
Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Lysozyme-induced 3D assembly of quercetin-zinc rod-like nanocolloids and its functional impact on antioxidant, gut microbiota, and lipid metabolism.Food chemistry: X · 2026Article
- Proteomics-based machine learning model for predicting secondary infection in HBV-related liver failure.Nature communications · 2026Article
- Starch-Based Polysaccharide Systems with Bioactive Substances: Physicochemical and Wettability Characteristics.International journal of molecular sciences · 2024Article
- Polymeric Nanoparticles for Biomedical Applications.Polymers · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Antibiotic abuse in the conventional treatment of microbial infections, such as inflammatory bowel disease, induces cumulative toxicity and antimicrobial resistance which requires the development of new antibiotics or novel strategies for infection control. Crosslinker-free polysaccharide-lysozyme microspheres were constructed via an electrostatic layer-by-layer self-assembly technique by adjusting the assembly behaviors of carboxymethyl starch (CMS) on lysozyme and subsequently outer cationic chitosan (CS) deposition. The relative enzymatic activity and in vitro release profile of lysozyme under simulated gastric and intestinal fluids were investigated. The highest loading efficiency of the optimized CS/CMS-lysozyme micro-gels reached 84.9% by tailoring CMS/CS content. The mild particle preparation procedure retained relative activity of 107.4% compared with free lysozyme, and successfully enhanced the antibacterial activity against
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Registered trials
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