ArticleNutrients2023
Metabolically Healthy Overweight and Obesity, Transition to Metabolically Unhealthy Status and Cognitive Function: Results from the Framingham Offspring Study.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Dementia risk by metabolic health and obesity in two prospective cohorts.BMC medicine · 2026Article
- Association of metabolic obesity phenotypes with cognitive decline in the ELSA-Brasil study.Diabetes, obesity & metabolism · 2026Article
- Correlation analysis of cognitive dysfunction and fluctuations in serum fibroblast growth factor 21 (FGF21) levels in the overweight group.Journal of medical biochemistry · 2026Article
- Understanding the role of visceral fat in metabolically healthy versus unhealthy obesity: a sex-based analysis of the transcriptome.Biology of sex differences · 2025Article
- Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation.European journal of clinical investigation · 2025Review
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- From healthy to unhealthy obesity: A longitudinal study of adults in ELSA-Brasil.PLOS global public health · 2025Article
- Association between physical activity and visceral adiposity index (VAI) in U.S. population with overweight or obesity: a cross-sectional study.BMC public health · 2024Article
- Associations between life's essential 8 and metabolic health among us adults: insights of NHANES from 2005 to 2018.Acta diabetologica · 2024Article
- Risk of Cardiovascular Events in Metabolically Healthy Overweight or Obese Adults: Role of LDL-Cholesterol in the Stratification of Risk.Diagnostics (Basel, Switzerland) · 2024Article
- Instability of Healthy Overweight and Obesity Phenotypes over the Long Term in Young Participants in the HARVEST Study: Influence of Sex.Journal of cardiovascular development and disease · 2024Article
- Relationship of Mitochondrial DNA Oxidation and Content with Metabolic Syndrome and Cardiovascular Risk in Obesity Phenotypes.Journal of obesity · 2024Article
- Examining sex differences in the association between sedentary behavior and cognitive function in bariatric surgery patients.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023Article
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10 authors.
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Abstract
aimsTo evaluate the association between metabolically healthy overweight/obesity (MHO) status and longitudinal cognitive function while also considering the stability of the condition.
methodsIn total, 2892 participants (mean age 60.7 (9.4) years) from Framingham Offspring Study completed health assessments every four years since 1971. Neuropsychological testing was repeated every four years starting from 1999 (Exam 7) to 2014 (Exam 9) (mean follow-up: 12.9 (3.5) years). Standardized neuropsychological tests were constructed into three factor scores (general cognitive performance, memory, processing speed/executive function). Healthy metabolic status was defined as the absence of all NCEP ATP III (2005) criteria (excluding waist circumference). MHO participants who scored positively for one or more of NCEP ATPIII parameters in the follow-up period were defined as unresilient MHO.
resultsNo significant difference on the change in cognitive function over time was observed between MHO and metabolically healthy normal weight (MHN) individuals (all
conclusionsRetaining a healthy metabolic status over time represents a more important discriminant in shaping cognitive function compared to body weight alone.
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