Evidence map›Paper›PMID 36904278›Full record

Trial reportNutrients2023

Delayed Macronutrients' Target Achievement in Parenteral Nutrition Reduces the Risk of Hyperglycemia in Preterm Newborn: A Randomized Controlled Trial.

Maria Di Chiara, Gianluigi Laccetta, Daniela Regoli, Lucia Dito, Caterina Spiriti, Benedetta De Santis, Elisa Travaglia, Rita Prota, Pasquale Parisi, Roberto Brunelli and 2 more

Full text readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Di ChiaraDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-6916-7800
Gianluigi LaccettaDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-7807-2870
Daniela RegoliDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Lucia DitoDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Caterina SpiritiDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Benedetta De SantisDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Elisa TravagliaDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Rita ProtaDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Pasquale ParisiDepartment of Neuroscience, Mental Health and Sense Organs (NESMOS), Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-9042-8120
Roberto BrunelliDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Giovanni BoscarinoDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-2481-0692
Gianluca TerrinDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-3541-2876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperglycemia (HG) is an independent risk factor of mortality and morbidity in very low birth weight newborns (VLBW). Achievement of high nutritional intakes in the first days of life (DoL) by parenteral nutrition (PN) increases the risk of HG. We aim to assess if a delayed achievement of the PN macronutrient target dose could reduce the occurrence of HG in VLBW. We enrolled 353 VLBW neonates in a randomized controlled clinical trial comparing two PN protocols that differed in the timing of energy and amino acid target dose achievement: (1) early target dose achievement (energy within 4-5 DoL; amino acids within 3-4 DoL) vs. (2) late target dose achievement (energy within 10-12 DoL; amino acids within 5-7 DoL). The primary outcome was the occurrence of HG during the first week of life. An additional endpoint was long-term body growth. We observed a significant difference in the rate of HG between the two groups (30.7% vs. 12.2%,

Indexed as

HyperglycemiaParenteral NutritionAmino AcidsHumansInfant, NewbornInfant, Very Low Birth WeightNutrientsAmino AcidsNutrientsamino acidsenergyEUGRgrowthintakeneonatesVLBW

Identifiers

PMID36904278
PMCPMC10005207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.